Protein Alignment 5-HT1B and HTR7

DIOPT Version :9

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_062873.1
• Gene: HTR7 / 3363
• HGNCID: 5302
• Length: 479
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 129/534 - (24%)
• Similarity: 195/534 - (36%)
• Gaps: 211/534 - (39%)

  Fly    88 VKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEI 152
            |:.:.:..:|.|:.|:||.||..|:.::...:.|:..:|||:.|||:|||.||..|||..:|.::
Human    79 VEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDL 143

  Fly   153 SNG-WILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWF 215
            ..| ||.|...|:::.:.||:||||||:.|..|:.|||..:|. :.|...:..:.:..||..||.
Human   144 IGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWL 208

  Fly   216 AALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKR 280
            .:..::|.|.|||.    ....:::.|::|||.||.|::|...||:|:.|:||:|::||..|||
Human   209 LSASITLPPLFGWA----QNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARK- 268

  Fly   281 IQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMR 345
                                            .|.:.:.....|...|
Human   269 --------------------------------SAAKHKFPGFPRVEPD----------------- 284

  Fly   346 ICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDA 410
                      :|:|
Human   285 ----------SVIA--------------------------------------------------- 288

  Fly   411 DDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTV 475
                   .|.|:.|.::|........:..|
Human   289 -------LNGIVKLQKEVEECANLSRLLKH----------------------------------- 311

  Fly   476 AGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIIT 540
                               |.||..:                        .|||:|||.||.||.
Human   312 -------------------ERKNISI------------------------FKREQKAATTLGIIV 333

  Fly   541 GAFVICWLPFFVMALTMS-LC-KECE-IHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRI 602
            |||.:||||||:::.... :| ..|. |...|...||||||.||.:||.||..||.:.|..::.:
Human   334 GAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSL 398

  Fly   603 L------FGRKAAA 610
            |      ..||.:|
Human   399 LQCQYRNINRKLSA 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	68/182 (37%)
HTR7	NP_062873.1	7tm_1	98..384	CDD:278431	114/485 (24%)
		7tm_4	98..>215	CDD:304433	43/116 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940