DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 5-HT1B and HTR5A

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_076917.1 Gene:HTR5A / 3361 HGNCID:5300 Length:357 Species:Homo sapiens


Alignment Length:576 Identity:152/576 - (26%)
Similarity:221/576 - (38%) Gaps:224/576 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 IELNGNLTQLVDTTSNLSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLM 100
            ::|..|||..  :.|..|.:..|.|:.          .||.:..:.:   |.|..:.:..:||.:
Human     1 MDLPVNLTSF--SLSTPSPLETNHSLG----------KDDLRPSSPL---LSVFGVLILTLLGFL 50

  Fly   101 ILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEIS-NGWILGPELCD 164
            :..|...|:.|:|.|:..|....|.:.||||:||:|:.||.|||||..|:|:| ..|.||..||.
Human    51 VAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQ 115

  Fly   165 IWTSCDVLCCTASILHLVAIAADRYWTVT-NIDYNNLRTPRRVF-LMIFCVWFAALIVSLAP-QF 226
            :|.:||||||||||.::.|||.||||::| :::| .|||.:.|. :||...|..:.::|||| .|
Human   116 LWIACDVLCCTASIWNVTAIALDRYWSITRHMEY-TLRTRKCVSNVMIALTWALSAVISLAPLLF 179

  Fly   227 GWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNV 291
            ||.: .|.:..||  |.||::..|.:|:|...||:||.|:||:|||||..|:.|:.         
Human   180 GWGE-TYSEGSEE--CQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVG--------- 232

  Fly   292 TLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTAN 356
                                                                     .|.||:.:
Human   233 ---------------------------------------------------------SRKTNSVS 240

  Fly   357 VVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEI 421
            .:                                                 |:|.:.:.|.....
Human   241 PI-------------------------------------------------SEAVEVKDSAKQPQ 256

  Fly   422 ITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSG 486
            :..:  |.|||                           .|..|                      
Human   257 MVFT--VRHAT---------------------------VTFQP---------------------- 270

  Fly   487 SGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFF 551
                    ||                         .....::|::||..:.|:.|.||:||:|||
Human   271 --------EG-------------------------DTWREQKEQRAALMVGILIGVFVLCWIPFF 302

  Fly   552 VMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRK 607
            :..|...|| .|:|.....|:||||||.||..||:|||.||..:..|||. .|.|:
Human   303 LTELISPLC-SCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKN-FFSRQ 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 7/25 (28%)
TM helix 2 125..151 CDD:320454 15/25 (60%)
TM helix 3 163..193 CDD:320454 19/29 (66%)
TM helix 4 204..226 CDD:320454 8/23 (35%)
TM helix 5 247..276 CDD:320454 15/28 (54%)
7tm_GPCRs <525..599 CDD:475119 33/73 (45%)
TM helix 6 533..555 CDD:410628 10/21 (48%)
TM helix 7 567..592 CDD:410628 14/24 (58%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 88/199 (44%)
HTR5ANP_076917.1 7tmA_5-HT5 41..349 CDD:320451 135/511 (26%)
TM helix 1 42..68 CDD:320451 7/25 (28%)
TM helix 2 75..101 CDD:320451 15/25 (60%)
TM helix 3 114..144 CDD:320451 19/29 (66%)
TM helix 4 156..177 CDD:320451 7/20 (35%)
TM helix 5 197..226 CDD:320451 15/28 (54%)
TM helix 6 278..308 CDD:320451 13/29 (45%)
TM helix 7 317..342 CDD:320451 14/24 (58%)

Return to query results.
Submit another query.