Protein Alignment 5-HT1B and HTR2C

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_000859.2
• Gene: HTR2C / 3358
• HGNCID: 5295
• Length: 458
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 126/594 - (21%)
• Similarity: 209/594 - (35%)
• Gaps: 243/594 - (40%)

  Fly    33 SLFIELNGNLTQLVD-TTSNLSQIV---WNRSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAM 93
            |..:.|.|.|....| :.|.::.||   :|.|..|.     |...|      .|:.|     .|:
Human    10 SFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGR-----FKFPD------GVQNW-----PAL 58

  Fly    94 AVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMP---LGAVYEISNG 155
            ::|  ::|::||.||:.||.|:.:|:.|.|..||.:.|||:||:.|..||||   |..:|:..
Human    59 SIV--IIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV-- 119

  Fly   156 WILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALI 219
            |.|...||.:|.|.|||..||||:||.||:.|||..:.| |:::...:..:..:.|..||..::.
Human   120 WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIG 184

  Fly   220 VSL-APQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLY-WKIYIIARKRIQ 282
            ||: .|..|.:|.:.: .:....|::: |..:.:..:...|::||.:::..| ..||::.|:.:.
Human   185 VSVPIPVIGLRDEEKV-FVNNTTCVLN-DPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALM 247

  Fly   283 RRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRIC 347
                                                                             
Human   248 ----------------------------------------------------------------- 247

  Fly   348 FGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADD 412
                                                                             
Human   248 ----------------------------------------------------------------- 247

  Fly   413 YRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAG 477
                                   |:..|    |.....:::..:.|....|..|:
Human   248 -----------------------LLHGH----TEEPPGLSLDFLKCCKRNTAEEE---------- 275

  Fly   478 AVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKR----------ERKA 532
                                           :.|||:|....||:..:.:|          ||||
Human   276 -------------------------------NSANPNQDQNARRRKKKERRPRGTMQAINNERKA 309

  Fly   533 AQTLAIITGAFVICWLPFFVMALTMSLC-KEC--EIHTAVASLFLWLGYFNSTLNPVIYTIFNPE 594
            ::.|.|:...|:|.|.|||:..:...|| |.|  ::...:.::|:|:||..|.:||::||:||..
Human   310 SKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKI 374

  Fly   595 FRRAFKRIL 603
            :||||...|
Human   375 YRRAFSNYL 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	10/25 (40%)
		TM helix 2	125..151	CDD:320454	13/28 (46%)
		TM helix 3	163..193	CDD:320454	17/29 (59%)
		TM helix 4	204..226	CDD:320454	6/22 (27%)
		TM helix 5	247..276	CDD:320454	7/29 (24%)
		7tm_GPCRs	<525..599	CDD:475119	30/86 (35%)
		TM helix 6	533..555	CDD:410628	8/21 (38%)
		TM helix 7	567..592	CDD:410628	9/24 (38%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	66/201 (33%)
HTR2C	NP_000859.2	7tmA_5-HT2C	54..385	CDD:341346	112/539 (21%)
		TM helix 1	55..81	CDD:341346	11/32 (34%)
		TM helix 2	88..114	CDD:341346	13/25 (52%)
		TM helix 3	127..157	CDD:341346	17/29 (59%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	151..153		1/1 (100%)
		TM helix 4	169..192	CDD:341346	6/22 (27%)
		TM helix 5	211..240	CDD:341346	6/28 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..301		8/67 (12%)
		TM helix 6	304..334	CDD:341346	12/29 (41%)
		TM helix 7	347..372	CDD:341346	9/24 (38%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	364..368		2/3 (67%)
		PDZ-binding	456..458