| Sequence 1: | NP_001137708.2 | Gene: | 5-HT1B / 37191 | FlyBaseID: | FBgn0263116 | Length: | 629 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000857.1 | Gene: | HTR1F / 3355 | HGNCID: | 5292 | Length: | 366 | Species: | Homo sapiens |
| Alignment Length: | 543 | Identity: | 155/543 - (28%) |
|---|---|---|---|
| Similarity: | 235/543 - (43%) | Gaps: | 190/543 - (34%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 66 NSNTFDLVDDEQERAAVEFWLLVKM---IAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANY 127
Fly 128 LVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTV 192
Fly 193 TN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQHCMVSQD-VGYQIFAT 255
Fly 256 CCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLE 320
Fly 321 AGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREE 385
Fly 386 TEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQS 450
Fly 451 IAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQ 515
Fly 516 KLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFN 580
Fly 581 STLNPVIYTIFNPEFRRAFKRIL 603 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| 5-HT1B | NP_001137708.2 | 7tm_1 | 107..>288 | CDD:278431 | 79/182 (43%) |
| HTR1F | NP_000857.1 | 7tmA_5-HT1F | 24..359 | CDD:320456 | 147/510 (29%) |
| TM helix 1 | 26..50 | CDD:320456 | 9/23 (39%) | ||
| TM helix 2 | 59..81 | CDD:320456 | 14/21 (67%) | ||
| TM helix 3 | 97..119 | CDD:320456 | 15/21 (71%) | ||
| Agonist binding. /evidence=ECO:0000250 | 99..108 | 4/8 (50%) | |||
| DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 | 120..122 | 1/1 (100%) | |||
| TM helix 4 | 142..158 | CDD:320456 | 5/15 (33%) | ||
| TM helix 5 | 179..202 | CDD:320456 | 9/22 (41%) | ||
| TM helix 6 | 292..314 | CDD:320456 | 16/21 (76%) | ||
| Agonist binding. /evidence=ECO:0000250 | 306..310 | 3/3 (100%) | |||
| TM helix 7 | 326..351 | CDD:320456 | 12/24 (50%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 343..347 | 2/3 (67%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165159544 | |
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D310620at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3253 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.880 | |||||