| Sequence 1: | NP_001137708.2 | Gene: | 5-HT1B / 37191 | FlyBaseID: | FBgn0263116 | Length: | 629 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000856.1 | Gene: | HTR1E / 3354 | HGNCID: | 5291 | Length: | 365 | Species: | Homo sapiens |
| Alignment Length: | 525 | Identity: | 146/525 - (27%) |
|---|---|---|---|
| Similarity: | 207/525 - (39%) | Gaps: | 197/525 - (37%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 89 KMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEIS 153
Fly 154 NGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAA 217
Fly 218 LIVSLAPQFGWKDPDYMKRIEEQHCMVSQD-VGYQIFATCCTFYVPLLVILFLYWKIYIIARKRI 281
Fly 282 QRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRI 346
Fly 347 CFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITRE--ETEFSTSNYD---NKSHAGTELTTV 406
Fly 407 SSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSG 471
Fly 472 AGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTL 536
Fly 537 AIITGAFVICWLPFFVMALTMSLCKECEIHTA---VASLFLWLGYFNSTLNPVIYTIFNPEFRRA 598
Fly 599 FKRIL 603 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| 5-HT1B | NP_001137708.2 | 7tm_1 | 107..>288 | CDD:278431 | 82/182 (45%) |
| HTR1E | NP_000856.1 | 7tmA_5-HT1E | 23..355 | CDD:320457 | 142/518 (27%) |
| TM helix 1 | 24..50 | CDD:320457 | 7/26 (27%) | ||
| TM helix 2 | 57..83 | CDD:320457 | 17/25 (68%) | ||
| TM helix 3 | 95..125 | CDD:320457 | 18/29 (62%) | ||
| Agonist binding. /evidence=ECO:0000250 | 98..107 | 4/8 (50%) | |||
| DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 | 119..121 | 1/1 (100%) | |||
| TM helix 4 | 137..159 | CDD:320457 | 8/21 (38%) | ||
| TM helix 5 | 179..208 | CDD:320457 | 14/28 (50%) | ||
| TM helix 6 | 284..314 | CDD:320457 | 17/29 (59%) | ||
| Agonist binding. /evidence=ECO:0000250 | 304..308 | 3/3 (100%) | |||
| TM helix 7 | 323..348 | CDD:320457 | 12/24 (50%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 340..344 | 2/3 (67%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165159545 | |
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D310620at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.850 | |||||