| Sequence 1: | NP_001137708.2 | Gene: | 5-HT1B / 37191 | FlyBaseID: | FBgn0263116 | Length: | 629 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000855.1 | Gene: | HTR1D / 3352 | HGNCID: | 5289 | Length: | 377 | Species: | Homo sapiens |
| Alignment Length: | 571 | Identity: | 161/571 - (28%) |
|---|---|---|---|
| Similarity: | 238/571 - (41%) | Gaps: | 197/571 - (34%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 42 LTQLVDTTSNLSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTII 106
Fly 107 GNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDV 171
Fly 172 LCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDYMK 235
Fly 236 RIEEQHCMV-SQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCD 299
Fly 300 SAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGA 364
Fly 365 VARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVA 429
Fly 430 HATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGT 494
Fly 495 EGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSL 559
Fly 560 CKE-CEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRKAA 609 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| 5-HT1B | NP_001137708.2 | 7tm_1 | 107..>288 | CDD:278431 | 76/182 (42%) |
| HTR1D | NP_000855.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..23 | 7/21 (33%) | |
| 7tmA_5-HT1B_1D | 35..367 | CDD:320455 | 144/514 (28%) | ||
| TM helix 1 | 40..66 | CDD:320455 | 10/25 (40%) | ||
| TM helix 2 | 73..99 | CDD:320455 | 14/25 (56%) | ||
| TM helix 3 | 111..141 | CDD:320455 | 21/29 (72%) | ||
| Agonist binding. /evidence=ECO:0000250 | 114..123 | 4/8 (50%) | |||
| DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 | 135..137 | 1/1 (100%) | |||
| TM helix 4 | 153..176 | CDD:320455 | 7/23 (30%) | ||
| TM helix 5 | 194..223 | CDD:320455 | 11/28 (39%) | ||
| TM helix 6 | 294..324 | CDD:320455 | 20/29 (69%) | ||
| Agonist binding. /evidence=ECO:0000250 | 314..318 | 3/3 (100%) | |||
| TM helix 7 | 335..360 | CDD:320455 | 13/24 (54%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 352..356 | 2/3 (67%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D310620at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3253 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.950 | |||||