Protein Alignment 5-HT1B and Adra1a

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_058887.2
• Gene: Adra1a / 29412
• RGDID: 2055
• Length: 466
• Species: Rattus norvegicus
• Alignment Length: 516
• Identity: 127/516 - (24%)
• Similarity: 198/516 - (38%)
• Gaps: 200/516 - (38%)

  Fly    89 KMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEIS 153
            |.|.:.|:||.:|:..::||:.||.::...|:|.:|.:|.:.:||||||.:...|:|..|::||.
  Rat    25 KAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIL 89

  Fly   154 NGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVT-NIDYNNLRTPRRVFLMIFCVWFAA 217
            ..|..|...|:||.:.|||||||||:.|..|:.|||..|: .:.|..:.|.||....:.|||..:
  Rat    90 GYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLS 154

  Fly   218 LIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQ 282
            |::|:.|.|||:.|   ...:|..|.::::.||.:|:...:|||||.:||.:|.::|::|::  :
  Rat   155 LVISIGPLFGWRQP---APEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKR--E 214

  Fly   283 RRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRIC 347
            .|..||   .|.....||       |:...|..||.:      |.:|.|
  Rat   215 SRGLKS---GLKTDKSDS-------EQVTLRIHRKNV------PAEGGG---------------- 247

  Fly   348 FGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADD 412
                                                      .|:..||:|...
  Rat   248 ------------------------------------------VSSAKNKTHFSV----------- 259

  Fly   413 YRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAG 477
                                                                             
  Rat   260 ----------------------------------------------------------------- 259

  Fly   478 AVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGA 542
                                                        :||:..||:|||:||.|:.|.
  Rat   260 --------------------------------------------RLLKFSREKKAAKTLGIVVGC 280

  Fly   543 FVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            ||:||||||::....|...:.:....|..:..||||.||.:||:||...:.||::||:.:|
  Rat   281 FVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	8/25 (32%)
		TM helix 2	125..151	CDD:320454	10/25 (40%)
		TM helix 3	163..193	CDD:320454	17/29 (59%)
		TM helix 4	204..226	CDD:320454	8/21 (38%)
		TM helix 5	247..276	CDD:320454	12/28 (43%)
		7tm_GPCRs	<525..599	CDD:475119	31/73 (42%)
		TM helix 6	533..555	CDD:410628	13/21 (62%)
		TM helix 7	567..592	CDD:410628	11/24 (46%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	74/196 (38%)
Adra1a	NP_058887.2	7tmA_alpha1A_AR	27..337	CDD:320448	123/508 (24%)
		TM helix 1	28..54	CDD:320448	8/25 (32%)
		TM helix 2	61..87	CDD:320448	10/25 (40%)
		TM helix 3	99..129	CDD:320448	17/29 (59%)
		TM helix 4	141..164	CDD:320448	8/22 (36%)
		TM helix 5	181..210	CDD:320448	12/28 (43%)
		TM helix 6	265..295	CDD:320448	17/29 (59%)
		TM helix 7	305..330	CDD:320448	11/24 (46%)
		Nuclear localization signal. /evidence=ECO:0000250	334..349		3/8 (38%)