Protein Alignment 5-HT1B and drd2a

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_898891.1
• Gene: drd2a / 282557
• ZFINID: ZDB-GENE-021119-2
• Length: 448
• Species: Danio rerio
• Alignment Length: 524
• Identity: 150/524 - (28%)
• Similarity: 234/524 - (44%)
• Gaps: 127/524 - (24%)

  Fly    94 AVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWIL 158
            |::|.|:|.|.:.|||.|..|:..|:.||...|||:.|||||||.||.||||.....|:...|..
Zfish    36 AMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRF 100

  Fly   159 GPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTNIDYNNLR--TPRRVFLMIFCVWFAALIVS 221
            ....|||:.:.||:.||||||:|.||:.|||..|......|.|  :.|||.:||..||..:..:|
Zfish   101 STIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISVVWILSFAIS 165

  Fly   222 LAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQ 286
            ....||..:   ....::..|::: :..:.::::..:||||.::.|.:|.:||::.||| ::|..
Zfish   166 CPLLFGLNN---TVTHDDALCVIA-NPAFVVYSSIVSFYVPFIITLLVYVQIYVVLRKR-RKRVN 225

  Fly   287 KSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRN 351
            ......:|:.|..|.:::...                  |.|               :::|
Zfish   226 TKRTCPVTDMDMSSTIKKCTH------------------PDD---------------VKLC---- 253

  Fly   352 TNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYR-- 414
                .|:..|.|              :..:..:...|              :..|.::.||.:
Zfish   254 ----TVIVKSSG--------------NCPVNNKNVIF--------------IKEVVNNGDDIQMD 286

  Fly   415 -TSNANEIITLSQQVAHATQHH--LIASHLNA--ITPLAQSIAMGGVGCLTTTTPSEKALSGAGT 474
             .:|.|......|..:..:|.:  |:.|:|..  |:|                 ||.:
Zfish   287 EITNRNPSRQRKQDQSGGSQQNSRLVNSNLRETDISP-----------------PSPE------- 327

  Fly   475 VAGAVAGGSGSGSGEEGAGTEGKNA----GVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQT 535
                 ||.....:|...:.|:|..|    ....|....|:    :.|.||:  :..::|:||.|.
Zfish   328 -----AGVKPERNGNTSSITKGAKAFEIQVSPTGKTQTSV----KTLNKRK--ISQQKEKKATQM 381

  Fly   536 LAIITGAFVICWLPFFVMALTMSLCK-ECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAF 599
            |||:.|.|:|||||||:..:..:.|: ..|::||    |.||||.||.:||:|||.||.|||:||
Zfish   382 LAIVLGVFIICWLPFFITHIVNTYCQVPPELYTA----FTWLGYVNSAVNPIIYTTFNIEFRKAF 442

  Fly   600 KRIL 603
            .:||
Zfish   443 IKIL 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	10/23 (43%)
		TM helix 2	125..151	CDD:320454	16/25 (64%)
		TM helix 3	163..193	CDD:320454	17/29 (59%)
		TM helix 4	204..226	CDD:320454	8/21 (38%)
		TM helix 5	247..276	CDD:320454	8/28 (29%)
		7tm_GPCRs	<525..599	CDD:475119	37/74 (50%)
		TM helix 6	533..555	CDD:410628	13/21 (62%)
		TM helix 7	567..592	CDD:410628	14/24 (58%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	74/194 (38%)
drd2a	NP_898891.1	7tmA_D2-like_dopamine_R	33..442	CDD:320181	146/518 (28%)
		TM helix 1	34..60	CDD:320181	10/23 (43%)
		TM helix 2	67..93	CDD:320181	16/25 (64%)
		TM helix 3	105..135	CDD:320181	17/29 (59%)
		TM helix 4	148..171	CDD:320181	8/22 (36%)
		TM helix 5	187..216	CDD:320181	8/28 (29%)
		TM helix 6	218..403	CDD:320181	55/289 (19%)
		TM helix 7	410..435	CDD:320181	15/28 (54%)