Protein Alignment 5-HT1B and Taar7e

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001010835.1
• Gene: Taar7e / 276742
• MGIID: 3527445
• Length: 358
• Species: Mus musculus
• Alignment Length: 541
• Identity: 105/541 - (19%)
• Similarity: 163/541 - (30%)
• Gaps: 269/541 - (49%)

  Fly    91 IAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG 155
            :.:..|.|...::.:.||:.|:.:|:..|.|.:.||:||||||.||..|...|||...|..:...
Mouse    48 LILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSTVRSVEGC 112

  Fly   156 WILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTNIDYNNLRTPRRVFLMIF--CVWFA-- 216
            |..|...|.:.|..||..|::||.||..|:.|||..|:    :.|..|.|....:.  |:.|:
Mouse   113 WYFGEIYCKLHTCFDVSFCSSSIFHLCFISVDRYIAVS----DPLIYPTRFTASVSNKCITFSWL 173

  Fly   217 -------ALIVSLAPQFGWKDPDYMKRIEEQHCM------VSQDVGYQIFATCCTFYVPLLVILF 268
                   :||.:.|.:.|.:|     .:....|:      |:|.   .:|.....|.:|.||::.
Mouse   174 LSISYGFSLIYTGASEAGLED-----LVSALTCVGGCQLAVNQS---WVFINFLLFLIPTLVMIT 230

  Fly   269 LYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTG 333
            :|.||::||:::
Mouse   231 VYSKIFLIAKQQ----------------------------------------------------- 242

  Fly   334 GQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSH 398
                                                                             
Mouse   243 ----------------------------------------------------------------- 242

  Fly   399 AGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTT 463
                               |..|..:|:|.|.|:..:
Mouse   243 -------------------AQNIEKMSKQTARASDSY---------------------------- 260

  Fly   464 PSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKR 528
                                                                   |.|   .|||
Mouse   261 -------------------------------------------------------KDR---VAKR 267

  Fly   529 ERKAAQTLAIITGAFVICWLPFFVMA--------LTMSLCKECEIHTAVASLFLWLGYFNSTLNP 585
            |||||:||.|...||::.|||:|:.:        :|         .|.|..:.:|:.|:||.:||
Mouse   268 ERKAAKTLGIAVAAFLLSWLPYFIDSFIDAFLGFIT---------PTYVYEILVWIAYYNSAMNP 323

  Fly   586 VIYTIFNPEFRRAFKRILFGR 606
            :||..|.|.||:|.|..:.|:
Mouse   324 LIYAFFYPWFRKAIKLTVTGK 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	6/25 (24%)
		TM helix 2	125..151	CDD:320454	15/25 (60%)
		TM helix 3	163..193	CDD:320454	13/29 (45%)
		TM helix 4	204..226	CDD:320454	6/32 (19%)
		TM helix 5	247..276	CDD:320454	8/28 (29%)
		7tm_GPCRs	<525..599	CDD:475119	32/81 (40%)
		TM helix 6	533..555	CDD:410628	10/29 (34%)
		TM helix 7	567..592	CDD:410628	10/24 (42%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	62/212 (29%)
Taar7e	NP_001010835.1	7tm_GPCRs	49..337	CDD:475119	102/531 (19%)
		TM helix 1	50..74	CDD:410628	6/23 (26%)
		TM helix 2	83..105	CDD:410628	13/21 (62%)
		TM helix 3	121..143	CDD:410628	9/21 (43%)
		TM helix 4	166..182	CDD:410628	2/15 (13%)
		TM helix 5	210..233	CDD:410628	6/25 (24%)
		TM helix 6	272..294	CDD:410628	10/21 (48%)
		TM helix 7	305..330	CDD:410628	10/24 (42%)