DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and adra2db

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_919346.1 Gene:adra2db / 266755 ZFINID:ZDB-GENE-021010-5 Length:415 Species:Danio rerio


Alignment Length:521 Identity:136/521 - (26%)
Similarity:216/521 - (41%) Gaps:154/521 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 IAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG 155
            :.:.:|:.::|||||:|||.|:.|:...|.|:...|..:.|||.||:.||.||:|.....|:...
Zfish    34 VLIVLVVTVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLAAADILVATLVIPFSLANEVMGY 98

  Fly   156 WILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALI 219
            |.||...|..:.:.|||.||:||:||.||:.||||:||. :.||..|||||:.:||..||..:.:
Zfish    99 WYLGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPRRIKIMITVVWVISAV 163

  Fly   220 VSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRR 284
            :|..|..       |.:.:|..|:::.:..|.:.:...:|:.|.|:::.:|.:||.:|:    :|
Zfish   164 ISFPPLL-------MTKHDELECLLNNETWYILSSCIVSFFAPGLIMILVYCRIYRVAK----QR 217

  Fly   285 AQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFG 349
            |...|            |.:...||...::|                              .||.
Zfish   218 ASTVF------------VAKNGMERQPSQSE------------------------------TCFV 240

  Fly   350 RNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYR 414
            |.                              .:.|.|..:|:.........||..:..:.....
Zfish   241 RK------------------------------GKSEVESPSSHSSGSRERKGELDDIDLEESSVS 275

  Fly   415 TSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAV 479
            ..:.|.....|::|.                           |..:...|:.: ||.|       
Zfish   276 NRHRNSRFAKSRKVE---------------------------GAQSCPKPNGR-LSWA------- 305

  Fly   480 AGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQL------LEAKRERKAAQTLAI 538
                                        .|.|:..::..:.|||      |...||::....||:
Zfish   306 ----------------------------CSRASELEQEPRARQLSLSKSKLAQMREKRFTFVLAV 342

  Fly   539 ITGAFVICWLPFFVMALTMSLC-KECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRI 602
            :.|.||:||.|||......::| |.|.|..::.:||.|:||.||::||:||||||.:||:|||:|
Zfish   343 VMGVFVLCWFPFFFTYSLHAICRKSCTIPDSLFNLFFWIGYCNSSVNPIIYTIFNRDFRKAFKKI 407

  Fly   603 L 603
            :
Zfish   408 M 408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 11/25 (44%)
TM helix 2 125..151 CDD:320454 11/25 (44%)
TM helix 3 163..193 CDD:320454 16/29 (55%)
TM helix 4 204..226 CDD:320454 8/21 (38%)
TM helix 5 247..276 CDD:320454 7/28 (25%)
7tm_GPCRs <525..599 CDD:475119 33/74 (45%)
TM helix 6 533..555 CDD:410628 10/21 (48%)
TM helix 7 567..592 CDD:410628 13/24 (54%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 72/196 (37%)
adra2dbNP_919346.1 7tmA_alpha-2D_AR 59..404 CDD:320447 121/490 (25%)
TM helix 2 68..94 CDD:320447 11/25 (44%)
TM helix 3 106..136 CDD:320447 16/29 (55%)
TM helix 4 148..171 CDD:320447 8/29 (28%)
TM helix 5 184..213 CDD:320447 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..299 13/151 (9%)
TM helix 6 331..361 CDD:320447 12/29 (41%)
TM helix 7 372..397 CDD:320447 13/24 (54%)

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