DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and adra2da

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_919345.2 Gene:adra2da / 266754 ZFINID:ZDB-GENE-021010-4 Length:408 Species:Danio rerio


Alignment Length:534 Identity:143/534 - (26%)
Similarity:218/534 - (40%) Gaps:160/534 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 AAVEFWLLVKMIAMAVVL--GLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACL 142
            |:...|...:..:..::|  .|:||:||:|||.||.|::..|.|:...|..:.|||.||:.||.|
Zfish    18 ASPRLWPYTEPASAIIILVVSLIILLTIVGNVLVIVAVLTSRALRAPQNLFLVSLACADILVATL 82

  Fly   143 VMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRV 206
            |:|.....||...|..|...|..:.:.|||.||:||:||.||:.||||:||. :.||..|||||:
Zfish    83 VIPFSLANEIMGYWYFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVRYNLKRTPRRI 147

  Fly   207 FLMIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYW 271
            ..||..||..:.::|..|..       |.:.:|:.|:::.:..|.:.:...:|:.|.|:::.:|.
Zfish   148 KCMIAVVWLISAVISFPPLI-------MTKHDEKECLINDETWYILSSCAVSFFAPGLIMITVYC 205

  Fly   272 KIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQL 336
            |||.:|:       |:|..|.:.:...                        ||.|          
Zfish   206 KIYRVAK-------QRSSTVFVAKNGL------------------------ERQP---------- 229

  Fly   337 QRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGT 401
                 .:...||.|.                              .:.|.|..:||....:....
Zfish   230 -----SQSETCFVRK------------------------------DKFEKESPSSNSSESAQRQE 259

  Fly   402 ELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSE 466
            ||       ||         |.|.:..|..::                                 
Zfish   260 EL-------DD---------IDLEESAASDSR--------------------------------- 275

  Fly   467 KALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAK---- 527
                         |.||.......   .||:..|......::..|  ||:...|:|.|.:|    
Zfish   276 -------------ARGSRFSKRRR---VEGERRGPQRSCRVSWAA--HQEPGSRQQQLASKSKVA 322

  Fly   528 --RERKAAQTLAIITGAFVICWLPFFVMALTMSLCKE-CEIHTAVASLFLWLGYFNSTLNPVIYT 589
              ||::....||::.|.||:||.|||......::|.| |....|:..||.|:||.||::||:|||
Zfish   323 QMREKRFTFVLAVVMGVFVLCWFPFFFTYSLQAVCGERCGPPEALFKLFFWIGYCNSSVNPIIYT 387

  Fly   590 IFNPEFRRAFKRIL 603
            |||.:||:|||:::
Zfish   388 IFNRDFRKAFKKVV 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 12/27 (44%)
TM helix 2 125..151 CDD:320454 11/25 (44%)
TM helix 3 163..193 CDD:320454 16/29 (55%)
TM helix 4 204..226 CDD:320454 8/21 (38%)
TM helix 5 247..276 CDD:320454 8/28 (29%)
7tm_GPCRs <525..599 CDD:475119 34/80 (43%)
TM helix 6 533..555 CDD:410628 10/21 (48%)
TM helix 7 567..592 CDD:410628 14/24 (58%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 72/198 (36%)
adra2daNP_919345.2 7tmA_alpha-2D_AR 44..397 CDD:320447 134/502 (27%)
TM helix 2 65..91 CDD:320447 11/25 (44%)
TM helix 3 103..133 CDD:320447 16/29 (55%)
TM helix 4 145..168 CDD:320447 8/29 (28%)
TM helix 5 181..210 CDD:320447 8/28 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..306 18/130 (14%)
TM helix 6 324..354 CDD:320447 12/29 (41%)
TM helix 7 365..390 CDD:320447 14/24 (58%)

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