DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and adra2b

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_997521.2 Gene:adra2b / 266751 ZFINID:ZDB-GENE-021010-2 Length:509 Species:Danio rerio


Alignment Length:582 Identity:156/582 - (26%)
Similarity:243/582 - (41%) Gaps:137/582 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 NGNG-------NSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILER 119
            ||.|       |.:...|.....|..|          |.|..:.||:|:||:||:.||.|::..|
Zfish    16 NGTGGTSSPTCNQSMIKLAPYSPEATA----------AFATAITLMMLITIVGNILVIIAVLTSR 70

  Fly   120 NLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAI 184
            :|:...|..:.|||.||:.||.|::|.....|:...|......|:|:.:.|||.||:||:||.||
Zfish    71 SLRGPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRSVWCEIYLALDVLFCTSSIVHLCAI 135

  Fly   185 AADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGW-KDPDYMKRIEEQHCMVSQD 247
            :.|||.:::. :.|...|||:|:...|..||..:.::|..|.... |:....:......|.::.:
Zfish   136 SLDRYMSISRAVTYGPKRTPKRIKCAILVVWLISAVISFPPLLSMNKNKGGGESGALPQCQLNDE 200

  Fly   248 VGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKR 312
            ..|.:::|..:|:.|.|:::.:|.:||.||::|               |.|...           
Zfish   201 RWYILYSTIGSFFAPCLIMILVYMRIYQIAKQR---------------TRCPPG----------- 239

  Fly   313 RAERKRLEAGERTPVD------GDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAA 371
             ..||...|...||..      ||.|.|.||::.|.                             
Zfish   240 -EPRKEAPANATTPQHKIQNGRGDETPGTLQKKARP----------------------------- 274

  Fly   372 IAVDFASLAITREETEFSTSN---YDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQ 433
                 .:||:::.|:....:|   .:|...|.:...|.::.......||::|:.....:.....:
Zfish   275 -----PTLAVSQVESVQQAANTPIANNLLQAPSTTLTPTTPCPSPSPSNSSEVAPSKSKEGKKEK 334

  Fly   434 HHLIASHLNAITP---LAQSIA------MGGVG----CLTTTTPS--------EKALSGAGTVAG 477
            ......:.|...|   ..:|::      .||.|    |..|.|||        :|......|..|
Zfish   335 KKKNNKNKNKKEPDNNNGESMSSDSDTEQGGRGLEVPCTPTMTPSGIHSPATMQKYRDMIATAKG 399

  Fly   478 AVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGA 542
            |           :....:.|..|           .|:.  |:|:.::  .||::....||::.|.
Zfish   400 A-----------KLVARKAKQDG-----------TPNS--ARRKAMV--NREKRFTFVLAVVIGV 438

  Fly   543 FVICWLPFFVMALTMSLCKE-CEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            |||||.|||......::|.| |.:...:...|.|:||.||.||||||||||.:||||||:||
Zfish   439 FVICWFPFFFSYSLQAVCPESCALPEPLFKFFFWIGYCNSCLNPVIYTIFNKDFRRAFKKIL 500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 12/25 (48%)
TM helix 2 125..151 CDD:320454 10/25 (40%)
TM helix 3 163..193 CDD:320454 16/29 (55%)
TM helix 4 204..226 CDD:320454 6/21 (29%)
TM helix 5 247..276 CDD:320454 8/28 (29%)
7tm_GPCRs <525..599 CDD:475119 35/74 (47%)
TM helix 6 533..555 CDD:410628 11/21 (52%)
TM helix 7 567..592 CDD:410628 14/24 (58%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 65/197 (33%)
adra2bNP_997521.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..284 16/95 (17%)

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