Protein Alignment 5-HT1B and adra2a

DIOPT Version :9

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_997520.3
• Gene: adra2a / 266750
• ZFINID: ZDB-GENE-021010-1
• Length: 388
• Species: Danio rerio
• Alignment Length: 528
• Identity: 146/528 - (27%)
• Similarity: 215/528 - (40%)
• Gaps: 159/528 - (30%)

  Fly    80 AAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVM 144
            |..|:.||| .:.::|.:||:||:.|.|||.||.|:...|.|:...|..:.|||.||:.||.|||
Zfish    13 ATKEYTLLV-ALPLSVAVGLLILLIIFGNVLVIIAVFTSRALRAPQNLFLVSLASADILVATLVM 76

  Fly   145 PLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFL 208
            |.....|:...|..|...|:|:.:.|||.|||||.||.||:.||||::|. |:||..|||:|:..
Zfish    77 PFSLANELMGMWTFGGVWCEIYLALDVLFCTASITHLCAISLDRYWSITQAIEYNLKRTPQRIKR 141

  Fly   209 MIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKI 273
            :||.||..|.::|..|..      .||:.|...|.::::..|.:.:...:|::|.::::.:|.:|
Zfish   142 IIFIVWIIAAVISCPPLI------TMKKSEGDICDINKEKWYIVSSCIGSFFLPCIIMVLVYIRI 200

  Fly   274 YIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQR 338
            |.||:||  .||...          |....|:.|:.:....:...::..|  |.|.|...|
Zfish   201 YQIAKKR--TRAPPG----------DHRKNEVGKKENDPHEKLNGIQNAE--PDDKDEING---- 247

  Fly   339 RTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTEL 403
                                                      :..||
Zfish   248 ------------------------------------------VDMEE------------------ 252

  Fly   404 TTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKA 468
                |.:.|::.||...:...|.:.         .:.|:.|.|
Zfish   253 ----SSSSDHKVSNPCSLKKKSSKG---------KTKLSQIKP---------------------- 282

  Fly   469 LSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAA 533
                           |.|...|...|...:...|                  ||    .||::..
Zfish   283 ---------------GDGDKTEACQTTKASRWKG------------------RQ----NREKRFT 310

  Fly   534 QTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRA 598
            ..||::.|.|||||.|||......:.| :|.:...:...|.|.||.||:|||:||||||.:|||:
Zfish   311 FVLAVVIGVFVICWFPFFFTYTFTAFC-DCCVPETLFKFFFWFGYCNSSLNPIIYTIFNNDFRRS 374

  Fly   599 FKRILFGR 606
            ||:||..|
Zfish   375 FKKILCRR 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	72/181 (40%)
adra2a	NP_997520.3	7tm_4	31..>165	CDD:304433	62/139 (45%)
		7tm_1	39..364	CDD:278431	121/481 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..291		23/208 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940