DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and ser-3

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_491954.1 Gene:ser-3 / 259744 WormBaseID:WBGene00004778 Length:610 Species:Caenorhabditis elegans


Alignment Length:611 Identity:163/611 - (26%)
Similarity:258/611 - (42%) Gaps:142/611 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 TQLVDTTSNLSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIG 107
            |.:.:.:.|.|...|:|:                  .:..:|:.:..:|:   ||.::::|.::|
 Worm    32 TPITEESPNCSFYEWSRN------------------PSHAQFFRIFSIIS---VLTVLVVVVVLG 75

  Fly   108 NVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEI-SNGWILGPELCDIWTSCDV 171
            |..||||::|.|.|::....|:.|||:|||.|..:::|.....|: ...||.|...|.||.:.|:
 Worm    76 NALVIAAVLLRRRLRSATGLLILSLALADLLVGTVILPFSIANEVLDQYWIFGETWCTIWLTLDI 140

  Fly   172 LCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQF----GWKDP 231
            ..|||||.:||||:.|||..:.. ::|..|.|..|....:..||..:.:: .:|.|    ..|| 
 Worm   141 WMCTASIYNLVAISIDRYIAIIKPLNYPMLVTKFRARCTVAIVWIGSFLI-CSPSFFLASSIKD- 203

  Fly   232 DYMKRIEEQHCMVS-QDVG--YQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTL 293
                  :|..|..: .:.|  |.:|:...:||:|:::::|:|::||:.||...:.......:||.
 Worm   204 ------KETPCRCTPANAGRVYVVFSASSSFYIPMIIVVFVYFRIYVAARAATKSIYSGMMSVTA 262

  Fly   294 TETDCDSAVRELKKERSKR-----------------RAERKRLEAGERTP-------------VD 328
            ...         ||:..|.                 |..|......:.||             :|
 Worm   263 AAN---------KKQNPKSYLLNHPDVINKDSLPMLRVHRGSSVVAQITPNKPYNTCRQNGNSID 318

  Fly   329 GDGTG-GQLQRRTRKRMRICFGRNTNTANVVAGSEGAV-ARSMAAIAVDFASLAITREETEFS-- 389
            ....| .|:.....|..:..   |.:...:|  :.||| |...|.|...|.......|.:..|  
 Worm   319 ATANGTSQITAAATKARKFA---NDSAKTLV--NRGAVGATQQAPIGARFKRHGRDSESSVDSMN 378

  Fly   390 -TSNYDNKSH-AGTELTTVSSDADDYRTS--NANEIITLSQQVAHATQHHLIASHLNAITPLAQS 450
             |::|....| :|.|  .:.|..::.|:|  ::||   .::|:.:.|..:...|:.|        
 Worm   379 GTNSYSATPHKSGNE--ELGSLIENSRSSSTDSNE---KTEQLTNQTDDNFSMSNNN-------- 430

  Fly   451 IAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQ 515
                                         ..|....:.:|...:|.|.....|......:....|
 Worm   431 -----------------------------NNGDEKEAFDESLLSESKKKSKSLASKFNHLMRRGQ 466

  Fly   516 KLAKRRQLLEAKR---ERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLG 577
            |  ||......||   |.|||:|:||:||.|:.|||.|   ||...|  |.:::..|.|:..|||
 Worm   467 K--KRTAGAYEKRLSLEIKAAKTVAIVTGCFIFCWLGF---ALVYGL--EIKLNDVVWSIVFWLG 524

  Fly   578 YFNSTLNPVIYTIFNPEFRRAFKRIL 603
            |.||.|||||||:||.|||..|||:|
 Worm   525 YLNSALNPVIYTVFNREFRICFKRLL 550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 9/25 (36%)
TM helix 2 125..151 CDD:320454 9/25 (36%)
TM helix 3 163..193 CDD:320454 16/29 (55%)
TM helix 4 204..226 CDD:320454 4/21 (19%)
TM helix 5 247..276 CDD:320454 10/30 (33%)
7tm_GPCRs <525..599 CDD:475119 40/76 (53%)
TM helix 6 533..555 CDD:410628 11/21 (52%)
TM helix 7 567..592 CDD:410628 15/24 (63%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 66/204 (32%)
ser-3NP_491954.1 7tmA_Octopamine_R 80..>252 CDD:320191 59/179 (33%)
TM helix 2 93..119 CDD:320191 9/25 (36%)
TM helix 3 132..162 CDD:320191 16/29 (55%)
TM helix 4 174..197 CDD:320191 5/23 (22%)
TM helix 5 216..245 CDD:320191 10/28 (36%)
7tm_GPCRs <479..546 CDD:475119 38/71 (54%)
TM helix 6 485..507 CDD:410628 13/24 (54%)
TM helix 7 514..539 CDD:410628 15/24 (63%)

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