DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and ser-6

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_741350.1 Gene:ser-6 / 259560 WormBaseID:WBGene00021897 Length:401 Species:Caenorhabditis elegans


Alignment Length:530 Identity:126/530 - (23%)
Similarity:207/530 - (39%) Gaps:149/530 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 MIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISN 154
            ||.:::.||::....:|||:.|...|:.:::||...|:||.||.::||.:..|::|...:.|.||
 Worm     1 MILLSLTLGVVNCFVVIGNLLVFYVILTKKSLQTSTNHLVLSLTISDLLLGILILPFAIIQEHSN 65

  Fly   155 GWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAAL 218
            .||.|...|.:|.|.||...||||.:|:||:.|||..|.. |.|..:.:.:.|.||.|.|||.:|
 Worm    66 EWIFGHFGCRLWLSVDVFLSTASIYNLLAISFDRYMAVRQPIKYPIISSTKVVRLMTFLVWFCSL 130

  Fly   219 IVS----LAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARK 279
            :::    :.......|.:..|..:.    .|....|.||:...:|.||..|::.|..:|:     
 Worm   131 LLAVILFVLLTLNAHDSEPTKDCQP----TSLPSMYIIFSAMASFIVPAFVMVILNVRIF----- 186

  Fly   280 RIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRM 344
                  |...:.:.|.|        :|.:....|..|                            
 Worm   187 ------QTVLHTSRTMT--------VKSKNGSLRVHR---------------------------- 209

  Fly   345 RICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSD 409
                                                  |:|.......:|       :..|..|.
 Worm   210 --------------------------------------RKEPIIPVKKHD-------KYETRLSH 229

  Fly   410 ADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGT 474
            .::...|.:.|:|.....||...:||. :|.::|  |..:|.       ||.|           .
 Worm   230 EEECVGSPSKEVIDPIPVVAVVEKHHK-SSAVDA--PAIRSF-------LTHT-----------V 273

  Fly   475 VAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVL-----ASIANPHQKLAKRRQLLEAKRERKAAQ 534
            |.|.:               |.|...: :..:.     :::.:|:....|:......:.|.:.|:
 Worm   274 VFGVL---------------EAKKTNI-INHITQWWRRSTVRSPNPSTRKKCMRRSLRTEIRVAR 322

  Fly   535 TLAIITGAFVICWLPFFVMALTMSLCKECEIHTAV--ASLF---LWLGYFNSTLNPVIYTIFNPE 594
            |..|:..||::||:||..:.:..:.. .|.:....  ||||   .||||.||.:||::|..|:.:
 Worm   323 TTGIVVAAFIVCWIPFTTIYVLQAYA-VCTVAAGCIPASLFTTAFWLGYSNSAVNPILYAAFSRD 386

  Fly   595 FRRAFKRILF 604
            ||.|.||:.|
 Worm   387 FRIALKRLFF 396

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 7/25 (28%)
TM helix 2 125..151 CDD:320454 9/25 (36%)
TM helix 3 163..193 CDD:320454 15/29 (52%)
TM helix 4 204..226 CDD:320454 8/25 (32%)
TM helix 5 247..276 CDD:320454 9/28 (32%)
7tm_GPCRs <525..599 CDD:475119 27/78 (35%)
TM helix 6 533..555 CDD:410628 9/21 (43%)
TM helix 7 567..592 CDD:410628 13/29 (45%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 63/200 (32%)
ser-6NP_741350.1 7tmA_amine_R-like 3..391 CDD:320098 120/521 (23%)
TM helix 1 3..29 CDD:320098 7/25 (28%)
TM helix 2 36..63 CDD:320098 9/26 (35%)
TM helix 3 74..104 CDD:320098 15/29 (52%)
TM helix 4 116..136 CDD:320098 8/19 (42%)
TM helix 5 158..314 CDD:320098 40/284 (14%)
TM helix 6 315..345 CDD:320098 10/29 (34%)
TM helix 7 359..384 CDD:320098 13/24 (54%)

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