Protein Alignment 5-HT1B and Htr5a

DIOPT Version :9

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_037280.1
• Gene: Htr5a / 25689
• RGDID: 2851
• Length: 357
• Species: Rattus norvegicus
• Alignment Length: 577
• Identity: 152/577 - (26%)
• Similarity: 219/577 - (37%)
• Gaps: 226/577 - (39%)

  Fly    36 IELNGNLTQL-VDTTSNLSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGL 99
            ::|..|||.. :.|.|.|..   |||:            |.|..|.:..|....:::.: .:||.
  Rat     1 MDLPINLTSFSLSTPSTLEP---NRSL------------DTEALRTSQSFLSAFRVLVL-TLLGF 49

  Fly   100 MILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEIS-NGWILGPELC 163
            :...|...|:.|:|.|:..|....|.:.||||:|::|:.||.|||||..|:|:| ..|.||..||
  Rat    50 LAAATFTWNLLVLATILRVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLC 114

  Fly   164 DIWTSCDVLCCTASILHLVAIAADRYWTVT-NIDYNNLRTPRRVF-LMIFCVWFAALIVSLAP-Q 225
            .:|.:||||||||||.::.|||.||||::| :::| .||..:||. :||...|..:.::|||| .
  Rat   115 QLWIACDVLCCTASIWNVTAIALDRYWSITRHLEY-TLRARKRVSNVMILLTWALSAVISLAPLL 178

  Fly   226 FGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFN 290
            |||.: .|.:..||  |.||::..|.:|:|...||:||.|:||:|||||..|:.|:
  Rat   179 FGWGE-TYSELSEE--CQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYKAAKFRM--------- 231

  Fly   291 VTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTA 355
                                                                             
  Rat   232 ----------------------------------------------------------------- 231

  Fly   356 NVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANE 420
                ||                                                    |.:|:..
  Rat   232 ----GS----------------------------------------------------RKTNSVS 240

  Fly   421 IITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGS 485
            .|..:.:|..|:||..:...:...|...|
  Rat   241 PIPEAVEVKDASQHPQMVFTVRHATVTFQ------------------------------------ 269

  Fly   486 GSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPF 550
                    |||                         .....::|::||..:.|:.|.||:||.||
  Rat   270 --------TEG-------------------------DTWREQKEQRAALMVGILIGVFVLCWFPF 301

  Fly   551 FVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRK 607
            ||..|...|| ..:|.....|:||||||.||..||:|||.||..:..||| :.|.::
  Rat   302 FVTELISPLC-SWDIPALWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFK-VFFSKQ 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	84/184 (46%)
Htr5a	NP_037280.1	7tm_GPCRs	41..349	CDD:421689	134/512 (26%)
		TM helix 1	42..68	CDD:410628	7/26 (27%)
		TM helix 2	75..101	CDD:410628	14/25 (56%)
		TM helix 3	114..144	CDD:410628	19/29 (66%)
		TM helix 4	156..177	CDD:410628	8/20 (40%)
		TM helix 5	197..226	CDD:410628	15/28 (54%)
		TM helix 6	278..308	CDD:410628	14/29 (48%)
		TM helix 7	317..342	CDD:410628	14/24 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5850
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010