DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and Drd4

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:XP_006230583.1 Gene:Drd4 / 25432 RGDID:2522 Length:389 Species:Rattus norvegicus


Alignment Length:524 Identity:141/524 - (26%)
Similarity:205/524 - (39%) Gaps:184/524 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 AMAVVLGLMIL-VTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG 155
            |.|:|.|:::: :.:.||..|..::..||.||...||.:.|||.|||.:|.||:||....|:..|
  Rat    34 AAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGG 98

  Fly   156 -WILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVT-NIDYNNLRTPRRVFLMIFCVWF--- 215
             |:|.|.|||...:.||:.|||||.:|.||:.||:..|| .:.||  :..:...|:|...|.   
  Rat    99 VWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYN--QQGQCQLLLIAATWLLSA 161

  Fly   216 --AALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIAR 278
              ||.:|........:||...       |:..:|  |.::::.|:|::|..::|.|||..:    
  Rat   162 AVAAPVVCGLNDVPGRDPTVC-------CLEDRD--YVVYSSICSFFLPCPLMLLLYWATF---- 213

  Fly   279 KRIQRRAQKSFNVTLTETDCDSAVRELK-KERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRK 342
             |..||.:              |.|..| ..|:.||      .:|...|| .|.|.|.|      
  Rat   214 -RGLRRWE--------------AARHTKLHSRAPRR------PSGPGPPV-SDPTQGPL------ 250

  Fly   343 RMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVS 407
                                                           .|:....|.:.....|||
  Rat   251 -----------------------------------------------FSDCPPPSPSLRTSPTVS 268

  Fly   408 SDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGA 472
            |..:.          .|||                  :|.:.       |||...          
  Rat   269 SRPES----------DLSQ------------------SPCSP-------GCLLPD---------- 288

  Fly   473 GTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAK---RERKAAQ 534
                                               |::|.|....::|::  .||   |||||.:
  Rat   289 -----------------------------------AALAQPPAPSSRRKR--GAKITGRERKAMR 316

  Fly   535 TLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAF 599
            .|.::.|||::||.||||:.:|.:||..|.:...:.|...||||.||.|||:||||||.|||..|
  Rat   317 VLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVF 381

  Fly   600 KRIL 603
            ::.|
  Rat   382 RKTL 385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 7/26 (27%)
TM helix 2 125..151 CDD:320454 13/25 (52%)
TM helix 3 163..193 CDD:320454 14/29 (48%)
TM helix 4 204..226 CDD:320454 6/26 (23%)
TM helix 5 247..276 CDD:320454 9/28 (32%)
7tm_GPCRs <525..599 CDD:475119 40/76 (53%)
TM helix 6 533..555 CDD:410628 10/21 (48%)
TM helix 7 567..592 CDD:410628 14/24 (58%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 69/202 (34%)
Drd4XP_006230583.1 7tm_GPCRs 44..381 CDD:475119 135/508 (27%)
TM helix 2 69..91 CDD:410628 13/21 (62%)
TM helix 3 108..130 CDD:410628 11/21 (52%)
TM helix 4 151..167 CDD:410628 5/15 (33%)
TM helix 5 187..210 CDD:410628 7/24 (29%)
TM helix 6 315..337 CDD:410628 10/21 (48%)
TM helix 7 349..374 CDD:410628 14/24 (58%)

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