Protein Alignment 5-HT1B and Htr1d

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_036984.1
• Gene: Htr1d / 25323
• RGDID: 2847
• Length: 374
• Species: Rattus norvegicus
• Alignment Length: 568
• Identity: 157/568 - (27%)
• Similarity: 227/568 - (39%)
• Gaps: 214/568 - (37%)

  Fly    52 LSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFW----LLVKMIAMAVVLGLMILVTIIGNVFVI 112
            |.|...|||:|..|                  .|    |....|::.|||.::.|.|::.|.||:
  Rat    11 LPQEASNRSLNATG------------------AWDPEVLQALRISLVVVLSIITLATVLSNAFVL 57

  Fly   113 AAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTAS 177
            ..|:|.:.|...||||:.|||..||.|:.||||:...|..:..|..|..|||||.|.|:.|||||
  Rat    58 TTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTAS 122

  Fly   178 ILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQH 241
            ||||..||.||||.:|: ::|:..||......||..||..::.:|:.|.| |:.....:.:.:
  Rat   123 ILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLF-WRQATAHEEMSD-- 184

  Fly   242 CMV-SQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVREL 305
            |:| :..:.|.|::||..||:|.::::.||.:||:.||.||.....
  Rat   185 CLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPS------------------- 230

  Fly   306 KKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMA 370
                                                     .:|:...||.::.||
  Rat   231 -----------------------------------------LYGKRFTTAQLITGS--------- 245

  Fly   371 AIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHH 435
                                        ||:.|.:::..                   .|.:..|
  Rat   246 ----------------------------AGSSLCSLNPS-------------------LHESHTH 263

  Fly   436 LIASHL--NAI-TPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGK 497
            .:.|.|  |.: ..||.||.
  Rat   264 TVGSPLFFNQVKIKLADSIL--------------------------------------------- 283

  Fly   498 NAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKE 562
                                  .|:.:.|.|||||.:||.||.|||:||||||||::|.:.:|::
  Rat   284 ----------------------ERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRD 326

  Fly   563 -CEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRKAA 609
             |.||.|:...|.||||.||.:||||||:||.:||:||:|::..|||:
  Rat   327 SCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	9/25 (36%)
		TM helix 2	125..151	CDD:320454	14/25 (56%)
		TM helix 3	163..193	CDD:320454	21/29 (72%)
		TM helix 4	204..226	CDD:320454	6/21 (29%)
		TM helix 5	247..276	CDD:320454	11/28 (39%)
		7tm_GPCRs	<525..599	CDD:475119	44/74 (59%)
		TM helix 6	533..555	CDD:410628	15/21 (71%)
		TM helix 7	567..592	CDD:410628	14/24 (58%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	80/197 (41%)
Htr1d	NP_036984.1	7tmA_5-HT1B_1D	32..364	CDD:320455	142/517 (27%)
		TM helix 1	37..63	CDD:320455	9/25 (36%)
		TM helix 2	70..96	CDD:320455	14/25 (56%)
		TM helix 3	108..138	CDD:320455	21/29 (72%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	132..134		1/1 (100%)
		TM helix 4	150..173	CDD:320455	7/23 (30%)
		TM helix 5	191..220	CDD:320455	11/28 (39%)
		TM helix 6	291..321	CDD:320455	21/29 (72%)
		TM helix 7	332..357	CDD:320455	14/24 (58%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	349..353		3/3 (100%)