DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and Htr1d

DIOPT Version :9

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_036984.1 Gene:Htr1d / 25323 RGDID:2847 Length:374 Species:Rattus norvegicus


Alignment Length:568 Identity:157/568 - (27%)
Similarity:227/568 - (39%) Gaps:214/568 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 LSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFW----LLVKMIAMAVVLGLMILVTIIGNVFVI 112
            |.|...|||:|..|                  .|    |....|::.|||.::.|.|::.|.||:
  Rat    11 LPQEASNRSLNATG------------------AWDPEVLQALRISLVVVLSIITLATVLSNAFVL 57

  Fly   113 AAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTAS 177
            ..|:|.:.|...||||:.|||..||.|:.||||:...|..:..|..|..|||||.|.|:.|||||
  Rat    58 TTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTAS 122

  Fly   178 ILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQH 241
            ||||..||.||||.:|: ::|:..||......||..||..::.:|:.|.| |:.....:.:.:  
  Rat   123 ILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLF-WRQATAHEEMSD-- 184

  Fly   242 CMV-SQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVREL 305
            |:| :..:.|.|::||..||:|.::::.||.:||:.||.||.....                   
  Rat   185 CLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPS------------------- 230

  Fly   306 KKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMA 370
                                                     .:|:...||.::.||         
  Rat   231 -----------------------------------------LYGKRFTTAQLITGS--------- 245

  Fly   371 AIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHH 435
                                        ||:.|.:::..                   .|.:..|
  Rat   246 ----------------------------AGSSLCSLNPS-------------------LHESHTH 263

  Fly   436 LIASHL--NAI-TPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGK 497
            .:.|.|  |.: ..||.||.                                             
  Rat   264 TVGSPLFFNQVKIKLADSIL--------------------------------------------- 283

  Fly   498 NAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKE 562
                                  .|:.:.|.|||||.:||.||.|||:||||||||::|.:.:|::
  Rat   284 ----------------------ERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRD 326

  Fly   563 -CEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRKAA 609
             |.||.|:...|.||||.||.:||||||:||.:||:||:|::..|||:
  Rat   327 SCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS 374

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 7tm_1 107..>288 CDD:278431 74/182 (41%)
Htr1dNP_036984.1 7tmA_5-HT1B_1D 32..364 CDD:320455 142/517 (27%)
TM helix 1 38..62 CDD:320455 9/23 (39%)
TM helix 2 71..93 CDD:320455 13/21 (62%)
TM helix 3 109..131 CDD:320455 15/21 (71%)
Agonist binding. /evidence=ECO:0000250 111..120 4/8 (50%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 132..134 1/1 (100%)
TM helix 4 154..170 CDD:320455 5/15 (33%)
TM helix 5 192..215 CDD:320455 8/22 (36%)
TM helix 6 297..319 CDD:320455 15/21 (71%)
Agonist binding. /evidence=ECO:0000250 311..315 3/3 (100%)
TM helix 7 332..357 CDD:320455 14/24 (58%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 349..353 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166353595
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D310620at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.850

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