Protein Alignment 5-HT1B and Htr2c

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_036897.2
• Gene: Htr2c / 25187
• RGDID: 2848
• Length: 460
• Species: Rattus norvegicus
• Alignment Length: 587
• Identity: 125/587 - (21%)
• Similarity: 210/587 - (35%)
• Gaps: 227/587 - (38%)

  Fly    33 SLFIELNGNLTQLVDTTSNLSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVL 97
            ||.:.|.|.|....|.:.:....:...:.|.:.....|...|      .|:.|     .|:::|
  Rat    10 SLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPD------GVQNW-----PALSIV- 62

  Fly    98 GLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMP---LGAVYEISNGWILG 159
             ::|::||.||:.||.|:.:|:.|.|..||.:.|||:||:.|..||||   |..:|:..  |.|.
  Rat    63 -VIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV--WPLP 124

  Fly   160 PELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSL- 222
            ..||.:|.|.|||..||||:||.||:.|||..:.| |:::...:..:..:.|..||..::.||:
  Rat   125 RYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVP 189

  Fly   223 APQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYW-KIYIIARKRIQRRAQ 286
            .|..|.:|...: .:....|::: |..:.:..:...|::||.:::..|: .||::.|:
  Rat   190 IPVIGLRDESKV-FVNNTTCVLN-DPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQ------- 245

  Fly   287 KSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRN 351
                                                                             
  Rat   246 ----------------------------------------------------------------- 245

  Fly   352 TNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTS 416
                                      :|.:.|..||             .||..:|
  Rat   246 --------------------------TLMLLRGHTE-------------EELANMS--------- 262

  Fly   417 NANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAG 481
                                    ||.:....:.
  Rat   263 ------------------------LNFLNCCCKK------------------------------- 272

  Fly   482 GSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQ-------LLEAKRERKAAQTLAII 539
               :|..||.|..                .||.||..::::       :.....|:||::.|.|:
  Rat   273 ---NGGEEENAPN----------------PNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIV 318

  Fly   540 TGAFVICWLPFFVMALTMSLC-KEC--EIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKR 601
            ...|:|.|.|||:..:...|| |.|  ::...:.::|:|:||..|.:||::||:||..:||||.:
  Rat   319 FFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSK 383

  Fly   602 IL 603
            .|
  Rat   384 YL 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	10/25 (40%)
		TM helix 2	125..151	CDD:320454	13/28 (46%)
		TM helix 3	163..193	CDD:320454	17/29 (59%)
		TM helix 4	204..226	CDD:320454	6/22 (27%)
		TM helix 5	247..276	CDD:320454	7/29 (24%)
		7tm_GPCRs	<525..599	CDD:475119	28/76 (37%)
		TM helix 6	533..555	CDD:410628	8/21 (38%)
		TM helix 7	567..592	CDD:410628	9/24 (38%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	66/201 (33%)
Htr2c	NP_036897.2	7tmA_5-HT2C	55..387	CDD:341346	115/536 (21%)
		TM helix 1	56..82	CDD:341346	11/32 (34%)
		TM helix 2	89..115	CDD:341346	13/25 (52%)
		TM helix 3	128..158	CDD:341346	17/29 (59%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	152..154		1/1 (100%)
		TM helix 4	170..193	CDD:341346	6/22 (27%)
		TM helix 5	212..241	CDD:341346	6/28 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	276..301		7/40 (18%)
		TM helix 6	306..336	CDD:341346	11/29 (38%)
		TM helix 7	349..374	CDD:341346	9/24 (38%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	366..370		2/3 (67%)
		PDZ-binding	458..460