Protein Alignment 5-HT1B and Drd1

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_036678.3
• Gene: Drd1 / 24316
• RGDID: 2518
• Length: 446
• Species: Rattus norvegicus
• Alignment Length: 556
• Identity: 133/556 - (23%)
• Similarity: 200/556 - (35%)
• Gaps: 232/556 - (41%)

  Fly    66 NSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQN-VANYLV 129
            |::|.|......||   :|..   .|..|..|.|:||.|::||..|.||:|..|:|:: |.|:.|
  Rat     4 NTSTMDEAGLPAER---DFSF---RILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFV 62

  Fly   130 ASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN 194
            .||||:||.||.||||..||.||:..|..| ..|:||.:.|::|.|||||:|..|:.||||.:::
  Rat    63 ISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISS 126

  Fly   195 -IDYNNLRTPRRVFLMIFCVWFAALIVSLAP-QFGWK--------DPDY--MKRIEEQHCMVSQD 247
             ..|....||:..|::|...|..::::|..| |..|.        |.::  ::..|:.:|.....
  Rat   127 PFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLS 191

  Fly   248 VGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKR 312
            ..|.|.::..:||:|:.:::..|..||.||:|:|
  Rat   192 RTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQI------------------------------- 225

  Fly   313 RAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFA 377
                :|:.|.||..|
  Rat   226 ----RRISALERAAV-------------------------------------------------- 236

  Fly   378 SLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLN 442
                                                                ||.
  Rat   237 ----------------------------------------------------HAK---------- 239

  Fly   443 AITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVL 507
                          .|.||                     :|:|:..|.|.:|....
  Rat   240 --------------NCQTT---------------------AGNGNPVECAQSESSFK-------- 261

  Fly   508 ASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECE-----IHT 567
                            :..|||.|..:||::|.|.||.||||||:....:..|...|     |.:
  Rat   262 ----------------MSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDS 310

  Fly   568 AVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            ....:|:|.|:.||:|||:||. ||.:|::||..:|
  Rat   311 ITFDVFVWFGWANSSLNPIIYA-FNADFQKAFSTLL 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	12/25 (48%)
		TM helix 2	125..151	CDD:320454	16/25 (64%)
		TM helix 3	163..193	CDD:320454	16/29 (55%)
		TM helix 4	204..226	CDD:320454	5/22 (23%)
		TM helix 5	247..276	CDD:320454	8/28 (29%)
		7tm_GPCRs	<525..599	CDD:475119	32/78 (41%)
		TM helix 6	533..555	CDD:410628	12/21 (57%)
		TM helix 7	567..592	CDD:410628	10/24 (42%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	77/208 (37%)
Drd1	NP_036678.3	7tm_GPCRs	22..341	CDD:475119	124/526 (24%)
		TM helix 1	25..49	CDD:320443	11/23 (48%)
		TM helix 2	59..81	CDD:320443	14/21 (67%)
		TM helix 3	96..118	CDD:320443	11/21 (52%)
		TM helix 4	141..157	CDD:320443	3/15 (20%)
		TM helix 5	192..215	CDD:320443	5/22 (23%)
		TM helix 6	271..293	CDD:320443	12/21 (57%)
		TM helix 7	310..335	CDD:320443	11/25 (44%)