Protein Alignment 5-HT1B and Taar8a

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001010830.1
• Gene: Taar8a / 215859
• MGIID: 2685076
• Length: 344
• Species: Mus musculus
• Alignment Length: 542
• Identity: 101/542 - (18%)
• Similarity: 168/542 - (30%)
• Gaps: 247/542 - (45%)

  Fly    91 IAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG 155
            :.:.:|.|...::.:.||:.|:.:::..:.|.:.||:|:||||.||..|...|||...|..|.:.
Mouse    32 VILYMVYGFGAVLAVCGNLLVVISVLHFKQLHSPANFLIASLASADFLVGISVMPFSMVRSIESC 96

  Fly   156 WILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTNIDYNNLRTPRRVFLMI--FCV---WF 215
            |..|...|.:.:.|||..|.:|:|||..|:.|||..||    :.|..|.:..:.:  .|:   |.
Mouse    97 WYFGDAFCSLHSCCDVAFCYSSVLHLCFISVDRYIAVT----DPLVYPTKFTVSVSGICISISWI 157

  Fly   216 AALIVSLAPQF-GWKDPDYMKRIEEQHC------MVSQDVGYQIFATCCTFYVPLLVILFLYWKI 273
            ..|:.|.|..: |.........:...:|      :::||.   :..:...|::|.||::.||.||
Mouse   158 LPLVYSSAVFYTGISAKGIESLVSALNCVGGCQIVINQDF---VLISFLLFFIPTLVMIILYSKI 219

  Fly   274 YIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQR 338
            :::|:::                    ||:
Mouse   220 FLVAKQQ--------------------AVK----------------------------------- 229

  Fly   339 RTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTEL 403
                                                                             
Mouse   230 ----------------------------------------------------------------- 229

  Fly   404 TTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKA 468
                                                                             
Mouse   230 ----------------------------------------------------------------- 229

  Fly   469 LSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAA 533
                  :..:|:|..|..|.|.                       |:...       ||||||||
Mouse   230 ------IETSVSGNRGESSSES-----------------------HKARV-------AKRERKAA 258

  Fly   534 QTLAIITGAFVICWLPFFVMALT---MSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEF 595
            :||.:...||::.|||:.:.||.   |.......::    .:..|..|:||.:||:||..|.|.|
Mouse   259 KTLGVTVVAFMVSWLPYTIDALVDAFMGFITPAYVY----EICCWGTYYNSAMNPLIYAFFFPWF 319

  Fly   596 RRAFKRILFGRKAAARARSAKI 617
            ::|.|.||.|......:.:|.:
Mouse   320 KKAIKLILSGEILKGHSSTANL 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	5/25 (20%)
		TM helix 2	125..151	CDD:320454	14/25 (56%)
		TM helix 3	163..193	CDD:320454	13/29 (45%)
		TM helix 4	204..226	CDD:320454	5/26 (19%)
		TM helix 5	247..276	CDD:320454	9/28 (32%)
		7tm_GPCRs	<525..599	CDD:475119	29/76 (38%)
		TM helix 6	533..555	CDD:410628	8/21 (38%)
		TM helix 7	567..592	CDD:410628	8/24 (33%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	58/207 (28%)
Taar8a	NP_001010830.1	7tm_GPCRs	32..323	CDD:475119	95/522 (18%)
		TM helix 1	34..58	CDD:320439	5/23 (22%)
		TM helix 2	67..89	CDD:320439	12/21 (57%)
		TM helix 3	105..127	CDD:320439	9/21 (43%)
		TM helix 4	150..166	CDD:320439	4/15 (27%)
		TM helix 5	194..217	CDD:320439	7/25 (28%)
		TM helix 6	258..280	CDD:320439	8/21 (38%)
		TM helix 7	291..316	CDD:320439	8/28 (29%)