Protein Alignment 5-HT1B and octr-1

DIOPT Version :9

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001024569.1
• Gene: octr-1 / 184469
• WormBaseID: WBGene00006411
• Length: 408
• Species: Caenorhabditis elegans
• Alignment Length: 525
• Identity: 147/525 - (28%)
• Similarity: 227/525 - (43%)
• Gaps: 157/525 - (29%)

  Fly    90 MIAMAVVLGLMILVTIIGNVFVIAAIILERNLQ-NVANYLVASLAVADLFVACLVMPLGAVYEIS 153
            ::.::.:|.:|:|: |.||:.|:..:..:|.|: ...|:|:.||||||:.|..|||||...|||.
 Worm    22 VLTISSMLTVMLLI-IFGNLLVVVTVYRDRKLRMQRQNWLIVSLAVADMLVGLLVMPLTLTYEIV 85

  Fly   154 NGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAA 217
            ..|.:|..||:||.:.|||..||||||:.||:.|||::||: :.|...|||.|:|:.|...|..:
 Worm    86 GEWTMGNILCEIWLALDVLFVTASILHICAISLDRYFSVTSPLTYPATRTPLRMFIYIGVSWIVS 150

  Fly   218 LIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQ 282
            |::.|.|.|||: |:.    .|..|.||.|:||.::::..:||:|:::::.:|.|||
 Worm   151 LLICLPPIFGWR-PER----AEGECSVSTDLGYVLYSSLGSFYIPVVILIIVYAKIY-------- 202

  Fly   283 RRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRR--TRKRMR 345
                   ::|:                   |..|:||:..||.    |.|...|..|  |.:|..
 Worm   203 -------SITI-------------------RHSRQRLKETERR----DHTLNMLTIRSSTNERYN 237

  Fly   346 ICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDA 410
            :.:....|:..:                         .:|.|...:|.|..:....:|..:|.:
 Worm   238 MEYELEENSDPI-------------------------EDEKEKVVTNRDMINKVCWQLRKISEE- 276

  Fly   411 DDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTV 475
                         |.:|....:    ||...|..:|.|..:         |....||..
 Worm   277 -------------LPRQGVKVS----IALDTNHNSPPASDL---------TRKLEEKKF------ 309

  Fly   476 AGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIIT 540
                                                     ..||::.|:|| ||:|...|.||.
 Worm   310 -----------------------------------------CEKRKRKLKAK-ERQATLLLGIIL 332

  Fly   541 GAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRA------- 598
            .||::.|||||::.:..:...|..  ..|...|.||||.||.:||||||:||.||:|.
 Worm   333 SAFILSWLPFFLIYVIGAFGHEAP--PLVFKFFFWLGYCNSGINPVIYTVFNREFKRGLCKQLHK 395

  Fly   599 FKRIL 603
            |:|.:
 Worm   396 FERFI 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	73/182 (40%)
octr-1	NP_001024569.1	7tmA_alpha2_AR	22..389	CDD:320187	145/512 (28%)
		TM helix 1	24..48	CDD:320187	7/24 (29%)
		TM helix 2	58..80	CDD:320187	14/21 (67%)
		TM helix 3	96..118	CDD:320187	13/21 (62%)
		TM helix 4	141..157	CDD:320187	4/15 (27%)
		TM helix 5	176..199	CDD:320187	5/22 (23%)
		TM helix 6	322..347	CDD:320187	12/24 (50%)
		TM helix 7	357..382	CDD:320187	14/24 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940