DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and octr-1

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_001024569.1 Gene:octr-1 / 184469 WormBaseID:WBGene00006411 Length:408 Species:Caenorhabditis elegans


Alignment Length:525 Identity:147/525 - (28%)
Similarity:227/525 - (43%) Gaps:157/525 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 MIAMAVVLGLMILVTIIGNVFVIAAIILERNLQ-NVANYLVASLAVADLFVACLVMPLGAVYEIS 153
            ::.::.:|.:|:|: |.||:.|:..:..:|.|: ...|:|:.||||||:.|..|||||...|||.
 Worm    22 VLTISSMLTVMLLI-IFGNLLVVVTVYRDRKLRMQRQNWLIVSLAVADMLVGLLVMPLTLTYEIV 85

  Fly   154 NGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAA 217
            ..|.:|..||:||.:.|||..||||||:.||:.|||::||: :.|...|||.|:|:.|...|..:
 Worm    86 GEWTMGNILCEIWLALDVLFVTASILHICAISLDRYFSVTSPLTYPATRTPLRMFIYIGVSWIVS 150

  Fly   218 LIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQ 282
            |::.|.|.|||: |:.    .|..|.||.|:||.::::..:||:|:::::.:|.|||        
 Worm   151 LLICLPPIFGWR-PER----AEGECSVSTDLGYVLYSSLGSFYIPVVILIIVYAKIY-------- 202

  Fly   283 RRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRR--TRKRMR 345
                   ::|:                   |..|:||:..||.    |.|...|..|  |.:|..
 Worm   203 -------SITI-------------------RHSRQRLKETERR----DHTLNMLTIRSSTNERYN 237

  Fly   346 ICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDA 410
            :.:....|:..:                         .:|.|...:|.|..:....:|..:|.: 
 Worm   238 MEYELEENSDPI-------------------------EDEKEKVVTNRDMINKVCWQLRKISEE- 276

  Fly   411 DDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTV 475
                         |.:|....:    ||...|..:|.|..:         |....||..      
 Worm   277 -------------LPRQGVKVS----IALDTNHNSPPASDL---------TRKLEEKKF------ 309

  Fly   476 AGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIIT 540
                                                     ..||::.|:|| ||:|...|.||.
 Worm   310 -----------------------------------------CEKRKRKLKAK-ERQATLLLGIIL 332

  Fly   541 GAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRA------- 598
            .||::.|||||::.:..:...|..  ..|...|.||||.||.:||||||:||.||:|.       
 Worm   333 SAFILSWLPFFLIYVIGAFGHEAP--PLVFKFFFWLGYCNSGINPVIYTVFNREFKRGLCKQLHK 395

  Fly   599 FKRIL 603
            |:|.:
 Worm   396 FERFI 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 7/25 (28%)
TM helix 2 125..151 CDD:320454 14/25 (56%)
TM helix 3 163..193 CDD:320454 17/29 (59%)
TM helix 4 204..226 CDD:320454 7/21 (33%)
TM helix 5 247..276 CDD:320454 10/28 (36%)
7tm_GPCRs <525..599 CDD:475119 35/80 (44%)
TM helix 6 533..555 CDD:410628 10/21 (48%)
TM helix 7 567..592 CDD:410628 14/24 (58%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 77/197 (39%)
octr-1NP_001024569.1 7tmA_alpha2_AR 22..389 CDD:320187 145/512 (28%)
TM helix 1 23..49 CDD:320187 7/26 (27%)
TM helix 2 57..83 CDD:320187 14/25 (56%)
TM helix 3 95..125 CDD:320187 17/29 (59%)
TM helix 4 137..160 CDD:320187 7/22 (32%)
TM helix 5 175..204 CDD:320187 10/43 (23%)
TM helix 6 319..349 CDD:320187 15/30 (50%)
TM helix 7 357..382 CDD:320187 14/24 (58%)

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