DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT1B and ser-2

DIOPT Version :9

Sequence 1:	NP_001137708.2	Gene:	5-HT1B / 37191	FlyBaseID:	FBgn0263116	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001024339.1	Gene:	ser-2 / 182110	WormBaseID:	WBGene00004777	Length:	455	Species:	Caenorhabditis elegans

Alignment Length:	535	Identity:	151/535 - (28%)
Similarity:	238/535 - (44%)	Gaps:	137/535 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 VKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEI 152
            |:::...:...::|.:|::||..|:.|:...|.|:.|.||.:.|||.:||.||..||||..|..:
Worm    55 VELVLGTITYLVIIAMTVVGNTLVVVAVFSYRPLKKVQNYFLVSLAASDLAVAIFVMPLHVVTFL 119

  Fly   153 SNG-WILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWF 215
            :.| |:||..:|..:|:.|:|.||:|||:|.|||.||||.:.| |:|...||.:.|.::|..||.
Worm   120 AGGKWLLGVTVCQFFTTADILLCTSSILNLCAIALDRYWAIHNPINYAQKRTTKFVCIVIVIVWI 184

  Fly   216 AALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKR 280
            .::::|:.|..||.  ::.:.:.|..|.:|.:..:.:|:...:|::||||::.:|.||:|.||:|
Worm   185 LSMLISVPPIIGWN--NWQENMMEDSCGLSTEKAFVVFSAAGSFFLPLLVMVVVYVKIFISARQR 247

  Fly   281 IQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMR 345
            |:....:|..:.:...:.|...|::..:|:...:.|.....||:||:
Worm   248 IRTNRGRSALMRIQNAEGDDDYRKMSIKRASVESARTSSRVGEKTPL------------------ 294

  Fly   346 ICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDA 410
                       |:|..:..|. ::||.:.|..||  .::||. ....|.|......::..|..|
Worm   295 -----------VIADGQTTVT-TLAAHSTDGGSL--PKDETT-KHMKYHNNGSCKVKVKDVKED- 343

  Fly   411 DDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTV 475

Worm   344 ----------------------------------------------------------------- 343

  Fly   476 AGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIIT 540
                               ||.             .||...|.||.::..|| |::||:|:|:|.
Worm   344 -------------------EGN-------------PNPTAVLRKREKISVAK-EKRAAKTIAVII 375

  Fly   541 GAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFG 605
            ..|..|||||||..:....|:.|::|..|...|.||||.||:|||.:|.|.|.|||||||:||.
Worm   376 FVFSFCWLPFFVAYVIRPFCETCKLHAKVEQAFTWLGYINSSLNPFLYGILNLEFRRAFKKILC- 439

  Fly   606 RKAAARARSAKIXFQ 620
            .||....|..:: .|
Worm   440 PKAVLEQRRRRMSAQ 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	72/182 (40%)
ser-2	NP_001024339.1	7tm_1	74..423	CDD:278431	132/482 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104614
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840