Protein Alignment 5-HT1B and DRD5

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_000789.1
• Gene: DRD5 / 1816
• HGNCID: 3026
• Length: 477
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 123/553 - (22%)
• Similarity: 187/553 - (33%)
• Gaps: 260/553 - (47%)

  Fly    91 IAMAVVLGLMILVTIIGNVFVIAAIILERNLQ-NVANYLVASLAVADLFVACLVMPLGAVYEISN 154
            :..|.:|.|:|:.|::|||.|.|||:..|:|: |:.|..:.||||:|||||.||||..||.|::.
Human    41 VVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAG 105

  Fly   155 GWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAAL 218
            .|..| ..||:|.:.|::|.|||||:|..|:.||||.::. ..|....|.|...:|:...|..::
Human   106 YWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSI 169

  Fly   219 IVSLAP-QFGWK---------------------------DPDYMKRIEEQHCMVSQDVGYQIFAT 255
            ::|..| |..|.                           :||    :..::|..|.:..|.|.::
Human   170 LISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPD----VNAENCDSSLNRTYAISSS 230

  Fly   256 CCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLE 320
            ..:||:|:.:::..|.:||.||:.:|:|                  :..|  ||:...|:.
Human   231 LISFYIPVAIMIVTYTRIYRIAQVQIRR------------------ISSL--ERAAEHAQS---- 271

  Fly   321 AGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREE 385
                                                         .||.||.|.|
Human   272 ---------------------------------------------CRSSAACAPD---------- 281

  Fly   386 TEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQS 450
                                                                       |.|..|
Human   282 -----------------------------------------------------------TSLRAS 287

  Fly   451 IAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQ 515
            |
Human   288 I---------------------------------------------------------------- 288

  Fly   516 KLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCK----------ECEIHTAVA 570
                       |:|.|..:||::|.|.||.||||||::...:..|.          .|...|..
Human   289 -----------KKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTF- 341

  Fly   571 SLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            .:|:|.|:.||:||||||. ||.:|::.|.::|
Human   342 DVFVWFGWANSSLNPVIYA-FNADFQKVFAQLL 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	12/25 (48%)
		TM helix 2	125..151	CDD:320454	16/25 (64%)
		TM helix 3	163..193	CDD:320454	16/29 (55%)
		TM helix 4	204..226	CDD:320454	5/22 (23%)
		TM helix 5	247..276	CDD:320454	8/28 (29%)
		7tm_GPCRs	<525..599	CDD:475119	32/83 (39%)
		TM helix 6	533..555	CDD:410628	12/21 (57%)
		TM helix 7	567..592	CDD:410628	12/24 (50%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	75/225 (33%)
DRD5	NP_000789.1	7tm_GPCRs	41..369	CDD:475119	121/547 (22%)
		TM helix 1	43..67	CDD:410628	12/23 (52%)
		TM helix 2	77..99	CDD:410628	14/21 (67%)
		TM helix 3	114..136	CDD:410628	11/21 (52%)
		TM helix 4	159..175	CDD:410628	3/15 (20%)
		TM helix 5	223..246	CDD:410628	5/22 (23%)
		TM helix 6	295..317	CDD:410628	12/21 (57%)
		TM helix 7	338..363	CDD:410628	13/26 (50%)