DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and DRD3

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_000787.2 Gene:DRD3 / 1814 HGNCID:3024 Length:400 Species:Homo sapiens


Alignment Length:175 Identity:36/175 - (20%)
Similarity:65/175 - (37%) Gaps:35/175 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  1963 SIHHSTSGTINSSSNSINSTNSNIHGGSL-----QIVQTAHIKSEKYTSSSSSSSTSSTSSTSSH 2022
            |:..|..|.:.:....|.:|.|.:....|     |:.|..:.:|   |......:....:||.:|
Human   117 SLSESAVGPVEACCLVIMATESKVAAEELCSLLSQVFQIVYTES---TIDFLDRAIFDGASTPTH 178

  Fly  2023 H--HHALKRTSPIVEHPAGTRPPKMLYTTSASAGGMDCGPDA-DMLHVP-----RGTVPGSSVVG 2079
            |  .|:...::.:        ..|..|...||.   .|.||: |:..:|     ..|.|.|..|.
Human   179 HLSLHSDDSSTKV--------DMKDSYDADAST---FCFPDSGDVGGLPPLPFCMQTSPHSKTVS 232

  Fly  2080 HS--------AVRGGLLVAPPLVMSPEINSLSSVVDDGRHHHQLH 2116
            .|        .::..:|.....:.|.||...::::.:.|:...:|
Human   233 ESELSTSATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIH 277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454
TM helix 2 125..151 CDD:320454
TM helix 3 163..193 CDD:320454
TM helix 4 204..226 CDD:320454
TM helix 5 247..276 CDD:320454
7tm_GPCRs <525..599 CDD:475119
TM helix 6 533..555 CDD:410628
TM helix 7 567..592 CDD:410628
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454
DRD3NP_000787.2 7tmA_D3_dopamine_R 30..394 CDD:320436 36/175 (21%)
TM helix 1 31..57 CDD:320436
TM helix 2 64..87 CDD:320436
TM helix 3 103..133 CDD:320436 3/15 (20%)
TM helix 4 150..168 CDD:320436 4/20 (20%)
TM helix 5 185..210 CDD:320436 7/35 (20%)
TM helix 6 322..352 CDD:320436
TM helix 7 362..387 CDD:320436
Blue background indicates that the domain is not in the aligned region.

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