Protein Alignment 5-HT1B and DRD1

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_000785.1
• Gene: DRD1 / 1812
• HGNCID: 3020
• Length: 446
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 127/530 - (23%)
• Similarity: 186/530 - (35%)
• Gaps: 225/530 - (42%)

  Fly    91 IAMAVVLGLMILVTIIGNVFVIAAIILERNLQN-VANYLVASLAVADLFVACLVMPLGAVYEISN 154
            |..|..|.|:||.|::||..|.||:|..|:|:: |.|:.|.||||:||.||.||||..||.||:.
Human    24 ILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAG 88

  Fly   155 GWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAAL 218
            .|..| ..|:||.:.|::|.|||||:|..|:.||||.::: ..|....||:..|::|...|..::
Human    89 FWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSV 152

  Fly   219 IVSLAP-QFGW--------KDPDYMKRIEE-QHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKI 273
            ::|..| |..|        .|.:.....|. .:|..|....|.|.::..:||:|:.:::..|.:|
Human   153 LISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRI 217

  Fly   274 YIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQR 338
            |.||:|:|:|
Human   218 YRIAQKQIRR------------------------------------------------------- 227

  Fly   339 RTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTEL 403
                                                                             
Human   228 ----------------------------------------------------------------- 227

  Fly   404 TTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKA 468
                             |..|.:...||.                        .|.|||
Human   228 -----------------IAALERAAVHAK------------------------NCQTTT------ 245

  Fly   469 LSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAA 533
                           |:|...|                   .:.|.....     :..|||.|..
Human   246 ---------------GNGKPVE-------------------CSQPESSFK-----MSFKRETKVL 271

  Fly   534 QTLAIITGAFVICWLPFFVMALTMSLCKECE-----IHTAVASLFLWLGYFNSTLNPVIYTIFNP 593
            :||::|.|.||.||||||::...:..|...|     |.:....:|:|.|:.||:|||:||. ||.
Human   272 KTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYA-FNA 335

  Fly   594 EFRRAFKRIL 603
            :||:||..:|
Human   336 DFRKAFSTLL 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	12/25 (48%)
		TM helix 2	125..151	CDD:320454	16/25 (64%)
		TM helix 3	163..193	CDD:320454	16/29 (55%)
		TM helix 4	204..226	CDD:320454	5/22 (23%)
		TM helix 5	247..276	CDD:320454	8/28 (29%)
		7tm_GPCRs	<525..599	CDD:475119	33/78 (42%)
		TM helix 6	533..555	CDD:410628	12/21 (57%)
		TM helix 7	567..592	CDD:410628	10/24 (42%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	79/207 (38%)
DRD1	NP_000785.1	7tmA_D1A_dopamine_R	23..341	CDD:320443	124/524 (24%)
		TM helix 1	25..51	CDD:320443	12/25 (48%)
		TM helix 2	59..86	CDD:320443	16/26 (62%)
		TM helix 3	96..126	CDD:320443	16/29 (55%)
		TM helix 4	138..161	CDD:320443	5/22 (23%)
		TM helix 5	191..221	CDD:320443	8/29 (28%)
		TM helix 6	265..295	CDD:320443	16/29 (55%)
		TM helix 7	310..335	CDD:320443	11/25 (44%)