DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and tyra-2

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_001033537.1 Gene:tyra-2 / 180970 WormBaseID:WBGene00017157 Length:468 Species:Caenorhabditis elegans


Alignment Length:550 Identity:138/550 - (25%)
Similarity:219/550 - (39%) Gaps:153/550 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 LGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPE 161
            |.|::|.||..|..|...:.....||.|.|.||.:||.:||.:..:|:||.:||.|:..|:....
 Worm    25 LFLLVLWTIFANSLVFIVLYKNPRLQTVPNLLVGNLAFSDLALGLIVLPLSSVYAIAGEWVFPDA 89

  Fly   162 LCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQ 225
            ||:::.|.|:||.||||.:|..:..||||.:|: :.|.:.|..|...:||..||.::.::||||.
 Worm    90 LCEVFVSADILCSTASIWNLSIVGLDRYWAITSPVAYMSKRNKRTAGIMILSVWISSALISLAPL 154

  Fly   226 FGWKD----PD--YMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIY---------- 274
            .|||.    |:  |.|....:.|.......|.:::...:|::|.|::.|:|:|||          
 Worm   155 LGWKQTAQTPNLIYEKNNTVRQCTFLDLPSYTVYSATGSFFIPTLLMFFVYFKIYQAFAKHRARQ 219

  Fly   275 ----------IIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDG 329
                      .:.||.|:.......:..|..:|      |..||..:.       |..|.:....
 Worm   220 IYRQKLAVSSHVIRKHIESTILHEISHVLPTSD------EFAKEEEEE-------EDSESSGQVE 271

  Fly   330 DGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYD 394
            :|.|                 |.|.|.:                          ||.|....:.|
 Worm   272 NGLG-----------------NGNDAII--------------------------EEDECEDEDSD 293

  Fly   395 NKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCL 459
            .|....|.:|||::                  .|...|:    |.::.....:::|:        
 Worm   294 EKRDDHTSMTTVTA------------------TVTGPTE----APYMKREAKISKSV-------- 328

  Fly   460 TTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLA---SIANPH------- 514
                |.||        ..|:.                |.....:..|:|   .....|       
 Worm   329 ----PIEK--------ESAIQ----------------KREAKPMRSVMAISYEKVKRHKNRKERI 365

  Fly   515 --QKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLG 577
              :.|.::.:.:.|.:||:..:.|.||.|.|.:||.|||.|.:.:..||:|..:..:.....|||
 Worm   366 YRKSLQRKPKAISAAKERRGVKVLGIILGCFTVCWAPFFTMYVLVQFCKDCSPNAHIEMFITWLG 430

  Fly   578 YFNSTLNPVIYTIFNPEFRRAFKRILFGRK 607
            |.||.:||:|||:||.:::.|.||:....|
 Worm   431 YSNSAMNPIIYTVFNRDYQIALKRLFTSEK 460

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 7/20 (35%)
TM helix 2 125..151 CDD:320454 11/25 (44%)
TM helix 3 163..193 CDD:320454 14/29 (48%)
TM helix 4 204..226 CDD:320454 9/21 (43%)
TM helix 5 247..276 CDD:320454 9/48 (19%)
7tm_GPCRs <525..599 CDD:475119 30/73 (41%)
TM helix 6 533..555 CDD:410628 11/21 (52%)
TM helix 7 567..592 CDD:410628 11/24 (46%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 70/216 (32%)
tyra-2NP_001033537.1 7tmA_amine_R-like 20..452 CDD:320098 134/540 (25%)
TM helix 1 20..46 CDD:320098 7/20 (35%)
TM helix 2 53..80 CDD:320098 12/26 (46%)
TM helix 3 91..121 CDD:320098 14/29 (48%)
TM helix 4 133..153 CDD:320098 7/19 (37%)
TM helix 5 182..379 CDD:320098 46/310 (15%)
TM helix 6 380..410 CDD:320098 13/29 (45%)
TM helix 7 420..445 CDD:320098 11/24 (46%)

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