Protein Alignment 5-HT1B and ser-7

DIOPT Version :9

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_741730.1
• Gene: ser-7 / 180565
• WormBaseID: WBGene00004780
• Length: 435
• Species: Caenorhabditis elegans
• Alignment Length: 520
• Identity: 135/520 - (25%)
• Similarity: 199/520 - (38%)
• Gaps: 176/520 - (33%)

  Fly    93 MAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWI 157
            :|:.:..||::|.:||..|..|::|.|.|::..|:|:.||||||.||..:||||..:..:.:.|.
 Worm    44 LAIAILAMIIMTTVGNALVCLAVLLVRKLKHPQNFLLVSLAVADFFVGLVVMPLALIDLLFDKWP 108

  Fly   158 LGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVS 221
            ||..:|.::|:.|:..|||||::|.||:.|||..::: :.|:..||.:|:.:.|.|||..|.|||
 Worm   109 LGSTMCSVYTTSDLTLCTASIVNLCAISVDRYLVISSPLRYSAKRTTKRIMMYIACVWIIAAIVS 173

  Fly   222 LAPQF---GWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQR 283
            ::...   ...|..|:.  :...|.|.....||.:||..:||.|..:::.|..||:..|
 Worm   174 ISSHIIANLLNDGTYVD--DTGTCQVIPHFIYQSYATIISFYAPTFIMVILNIKIWRAA------ 230

  Fly   284 RAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICF 348
                                             |||.|.:|.                  |..|
 Worm   231 ---------------------------------KRLAAQDRL------------------MSHC- 243

  Fly   349 GRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDY 413
                   |.|..||.  .|:.:|...||.:                       |..|:.....:.
 Worm   244 -------NSVDASER--PRNGSAETKDFLN-----------------------EKETIDVPKKER 276

  Fly   414 RTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGA 478
            ..|..:.:..|.::..|.......|    |..||.:.
 Worm   277 ANSTNSRLFKLERKYLHRPSAFFSA----AKGPLIRQ---------------------------- 309

  Fly   479 VAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAF 543
                           ||                               |.|.||.:||.:|...|
 Worm   310 ---------------TE-------------------------------KSECKARKTLGVIMSVF 328

  Fly   544 VICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRKA 608
            :|||||||::|:..|.  ...|...:..|.|||||.||||||:||..:|.|||..|:.:|..|.|
 Worm   329 IICWLPFFILAIFKSF--GMWIPDWLDLLALWLGYSNSTLNPLIYCKYNKEFRIPFREMLACRCA 391

  Fly   609  608
             Worm   392  391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	65/184 (35%)
ser-7	NP_741730.1	7tmA_5-HT7	42..382	CDD:320452	131/509 (26%)
		TM helix 1	44..68	CDD:320452	8/23 (35%)
		TM helix 2	77..99	CDD:320452	14/21 (67%)
		TM helix 3	115..137	CDD:320452	10/21 (48%)
		TM helix 4	160..176	CDD:320452	8/15 (53%)
		TM helix 5	201..224	CDD:320452	8/22 (36%)
		TM helix 6	315..340	CDD:320452	13/24 (54%)
		TM helix 7	350..375	CDD:320452	14/24 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940