Protein Alignment 5-HT1B and Htr2c

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_032338.3
• Gene: Htr2c / 15560
• MGIID: 96281
• Length: 459
• Species: Mus musculus
• Alignment Length: 587
• Identity: 125/587 - (21%)
• Similarity: 209/587 - (35%)
• Gaps: 228/587 - (38%)

  Fly    33 SLFIELNGNLTQLVDTTSNLSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVL 97
            ||.:.|.|.|....|.:.:....:...:.|.:.....|...|      .|:.|     .|:::|
Mouse    10 SLLVHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPD------GVQNW-----PALSIV- 62

  Fly    98 GLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMP---LGAVYEISNGWILG 159
             ::|::||.||:.||.|:.:|:.|.|..||.:.|||:||:.|..||||   |..:|:..  |.|.
Mouse    63 -VIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV--WPLP 124

  Fly   160 PELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSL- 222
            ..||.:|.|.|||..||||:||.||:.|||..:.| |:::...:..:..:.|..||..::.||:
Mouse   125 RYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVP 189

  Fly   223 APQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYW-KIYIIARKRIQRRAQ 286
            .|..|.:|...: .:....|::: |..:.:..:...|::||.:::..|: .||::.|:
Mouse   190 IPVIGLRDESKV-FVNNTTCVLN-DPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQ------- 245

  Fly   287 KSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRN 351
                                                                             
Mouse   246 ----------------------------------------------------------------- 245

  Fly   352 TNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTS 416
                                      :|.:.|..||             .||..:|
Mouse   246 --------------------------TLMLLRGHTE-------------EELRNIS--------- 262

  Fly   417 NANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAG 481
                                    ||.:....:
Mouse   263 ------------------------LNFLKCCCK-------------------------------- 271

  Fly   482 GSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQ-------LLEAKRERKAAQTLAII 539
               .|..||.|..                .||.||..::::       :.....|:||::.|.|:
Mouse   272 ---KGDEEENAPN----------------PNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIV 317

  Fly   540 TGAFVICWLPFFVMALTMSLC-KEC--EIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKR 601
            ...|:|.|.|||:..:...|| |.|  ::...:.::|:|:||..|.:||::||:||..:||||.:
Mouse   318 FFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSK 382

  Fly   602 IL 603
            .|
Mouse   383 YL 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	10/25 (40%)
		TM helix 2	125..151	CDD:320454	13/28 (46%)
		TM helix 3	163..193	CDD:320454	17/29 (59%)
		TM helix 4	204..226	CDD:320454	6/22 (27%)
		TM helix 5	247..276	CDD:320454	7/29 (24%)
		7tm_GPCRs	<525..599	CDD:475119	28/76 (37%)
		TM helix 6	533..555	CDD:410628	8/21 (38%)
		TM helix 7	567..592	CDD:410628	9/24 (38%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	66/201 (33%)
Htr2c	NP_032338.3	7tmA_5-HT2C	55..386	CDD:341346	115/536 (21%)
		TM helix 1	56..82	CDD:341346	11/32 (34%)
		TM helix 2	89..115	CDD:341346	13/25 (52%)
		TM helix 3	128..158	CDD:341346	17/29 (59%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	152..154		1/1 (100%)
		TM helix 4	170..193	CDD:341346	6/22 (27%)
		TM helix 5	212..241	CDD:341346	6/28 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..302		7/43 (16%)
		TM helix 6	305..335	CDD:341346	11/29 (38%)
		TM helix 7	348..373	CDD:341346	9/24 (38%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	365..369		2/3 (67%)
		PDZ-binding	457..459