Protein Alignment 5-HT1B and Htr1f

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_032336.1
• Gene: Htr1f / 15557
• MGIID: 99842
• Length: 366
• Species: Mus musculus
• Alignment Length: 521
• Identity: 148/521 - (28%)
• Similarity: 221/521 - (42%)
• Gaps: 187/521 - (35%)

  Fly    89 KMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEIS 153
            |::....:.||.::.|.| |..||||||:.|.|.:.||||:.||||.|..||.||||...||.:.
Mouse    23 KILVSLTLSGLALMTTTI-NSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVR 86

  Fly   154 NGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAA 217
            ..||:|..|||||.|.|::|||.|||||.|||.|||..:|: ::|...||||...:||..||..:
Mouse    87 ESWIMGQVLCDIWLSVDIICCTCSILHLSAIALDRYRAITDAVEYARKRTPRHAGIMITIVWVIS 151

  Fly   218 LIVSLAPQFGWKDPDYMKRIEEQHCMVSQD-VGYQIFATCCTFYVPLLVILFLYWKIYIIARKRI 281
            :.:|:.|.| |:   :.....:..|::..| :...|::|...||:||::||.||:|||..||...
Mouse   152 VFISMPPLF-WR---HQGTSRDDECVIKHDHIVSTIYSTFGAFYIPLVLILILYYKIYRAARTLY 212

  Fly   282 QRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRI 346
            .:|               .|.|.:|:|.:    .:..||:||::
Mouse   213 HKR---------------QASRMIKEELN----GQVFLESGEKS--------------------- 237

  Fly   347 CFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDAD 411
                                                                             
Mouse   238 ----------------------------------------------------------------- 237

  Fly   412 DYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVA 476
                                                        :..::|:...||:||...|
Mouse   238 --------------------------------------------IKLVSTSYMLEKSLSDPST-- 256

  Fly   477 GAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKL----AKRRQLLEAKRERKAAQTLA 537
                                     ....:.:::.:|..:|    :.|||.:...||||||.||.
Mouse   257 -------------------------DFDRIHSTVKSPRSELKHEKSWRRQKISGTRERKAATTLG 296

  Fly   538 IITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRI 602
            :|.||||||||||||..|.:::|::|:|...:::...||||.||.:||:||||||.:|::||:::
Mouse   297 LILGAFVICWLPFFVKELVVNVCEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKL 361

  Fly   603 L 603
            :
Mouse   362 V 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	11/25 (44%)
		TM helix 2	125..151	CDD:320454	16/25 (64%)
		TM helix 3	163..193	CDD:320454	20/29 (69%)
		TM helix 4	204..226	CDD:320454	7/21 (33%)
		TM helix 5	247..276	CDD:320454	14/29 (48%)
		7tm_GPCRs	<525..599	CDD:475119	40/73 (55%)
		TM helix 6	533..555	CDD:410628	16/21 (76%)
		TM helix 7	567..592	CDD:410628	12/24 (50%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	86/197 (44%)
Htr1f	NP_032336.1	7tmA_5-HT1F	24..359	CDD:320456	146/515 (28%)
		TM helix 1	25..51	CDD:320456	11/26 (42%)
		TM helix 2	58..84	CDD:320456	16/25 (64%)
		TM helix 3	96..126	CDD:320456	20/29 (69%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	120..122		1/1 (100%)
		TM helix 4	138..160	CDD:320456	7/21 (33%)
		TM helix 5	178..207	CDD:320456	13/28 (46%)
		TM helix 6	286..316	CDD:320456	22/29 (76%)
		TM helix 7	326..351	CDD:320456	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	343..347		2/3 (67%)