| Sequence 1: | NP_001137708.2 | Gene: | 5-HT1B / 37191 | FlyBaseID: | FBgn0263116 | Length: | 629 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001272411.1 | Gene: | Htr1d / 15552 | MGIID: | 96276 | Length: | 374 | Species: | Mus musculus |
| Alignment Length: | 566 | Identity: | 155/566 - (27%) |
|---|---|---|---|
| Similarity: | 225/566 - (39%) | Gaps: | 214/566 - (37%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 52 LSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFW----LLVKMIAMAVVLGLMILVTIIGNVFVI 112
Fly 113 AAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTAS 177
Fly 178 ILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQH 241
Fly 242 CMV-SQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVREL 305
Fly 306 KKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMA 370
Fly 371 AIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHH 435
Fly 436 LIASHL--NAI-TPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGK 497
Fly 498 NAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKE 562
Fly 563 -CEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRK 607 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| 5-HT1B | NP_001137708.2 | 7tm_1 | 107..>288 | CDD:278431 | 74/182 (41%) |
| Htr1d | NP_001272411.1 | 7tm_GPCRs | 32..364 | CDD:391938 | 142/517 (27%) |
| TM helix 1 | 38..62 | CDD:341315 | 9/23 (39%) | ||
| TM helix 2 | 71..93 | CDD:341315 | 13/21 (62%) | ||
| TM helix 3 | 109..131 | CDD:341315 | 15/21 (71%) | ||
| Agonist binding. /evidence=ECO:0000250 | 111..120 | 4/8 (50%) | |||
| DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 | 132..134 | 1/1 (100%) | |||
| TM helix 4 | 154..170 | CDD:341315 | 5/15 (33%) | ||
| TM helix 5 | 192..215 | CDD:341315 | 8/22 (36%) | ||
| TM helix 6 | 294..319 | CDD:341315 | 18/24 (75%) | ||
| Agonist binding. /evidence=ECO:0000250 | 311..315 | 3/3 (100%) | |||
| TM helix 7 | 332..357 | CDD:341315 | 14/24 (58%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 349..353 | 3/3 (100%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C167849917 | |
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3253 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.870 | |||||