Protein Alignment 5-HT1B and Htr1a

DIOPT Version :9

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_032334.2
• Gene: Htr1a / 15550
• MGIID: 96273
• Length: 421
• Species: Mus musculus
• Alignment Length: 555
• Identity: 176/555 - (31%)
• Similarity: 256/555 - (46%)
• Gaps: 160/555 - (28%)

  Fly    63 GNGNSNT-----FDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQ 122
            |.||:.|     |....::...:.|.|   ...:..:::||.:|...::||..|:|||.|||:||
Mouse     7 GQGNNTTTSLEPFGTGGNDTGLSNVTF---SYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQ 68

  Fly   123 NVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAAD 187
            ||||||:.||||.||.|:.||:|:.|:|::.|.|.||...||::.:.||||||:|||||.|||.|
Mouse    69 NVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALD 133

  Fly   188 RYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQ 251
            |||.:|: |||.|.|||||...:|...|....::|:.|..||:.|:  .|.....|.:|:|.||.
Mouse   134 RYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPE--DRSNPNECTISKDHGYT 196

  Fly   252 IFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAER 316
            |::|...||:|||::|.||.:|:..||.||::..:|                          .|:
Mouse   197 IYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKK--------------------------VEK 235

  Fly   317 KRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNT-----NTANVVAGSEGAVARSM--AAIAV 374
            |           |.||.              ||.::     .:.|...|| |...||.  .|:..
Mouse   236 K-----------GAGTS--------------FGTSSAPPPKKSLNGQPGS-GDCRRSAENRAVGT 274

  Fly   375 DFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIAS 439
            ..|:.|:.:.|.:           |..|:..|      :|..|:.                   .
Mouse   275 PCANGAVRQGEDD-----------ATLEVIEV------HRVGNSK-------------------G 303

  Fly   440 HLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLG 504
            ||    ||                |||   |||.:.
Mouse   304 HL----PL----------------PSE---SGATSY----------------------------- 316

  Fly   505 GVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCK-ECEIHTA 568
             |.|.:...:::.|:.::.:...||||..:||.||.|.|::||||||::||.:..|: .|.:...
Mouse   317 -VPACLERKNERTAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPEL 380

  Fly   569 VASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            :.::..||||.||.||||||..||.:|:.|||:|:
Mouse   381 LGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	91/181 (50%)
Htr1a	NP_032334.2	7tm_4	48..>169	CDD:304433	65/120 (54%)
		7tm_1	53..400	CDD:278431	157/489 (32%)
		Agonist binding. /evidence=ECO:0000250	112..121		4/8 (50%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	133..135		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	237..268		11/45 (24%)
		Agonist binding. /evidence=ECO:0000250	358..362		3/3 (100%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	396..400		3/3 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1821
eggNOG	1	0.900	-	-		E33208_3BCYC
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310620at33208
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104614
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.850