DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and ADRB2

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_000015.2 Gene:ADRB2 / 154 HGNCID:286 Length:413 Species:Homo sapiens


Alignment Length:563 Identity:129/563 - (22%)
Similarity:197/563 - (34%) Gaps:233/563 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 GNSNTFDLV---------DDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERN 120
            ||.:.|.|.         |..|||.  |.|    ::.|.:|:.|::|..:.|||.||.||.....
Human     5 GNGSAFLLAPNGSHAPDHDVTQERD--EVW----VVGMGIVMSLIVLAIVFGNVLVITAIAKFER 63

  Fly   121 LQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIA 185
            ||.|.||.:.|||.|||.:...|:|.||.:.:...|..|...|:.|||.||||.||||..|..||
Human    64 LQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIA 128

  Fly   186 ADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAP-QFGWKDPDYMKRI----EEQHCMV 244
            .|||:.:|: ..|.:|.|..:..::|..||..:.:.|..| |..|....:.:.|    .|..|..
Human   129 VDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDF 193

  Fly   245 SQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKER 309
            ..:..|.|.::..:|||||::::|:|.:::..|::::|                       |.::
Human   194 FTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQ-----------------------KIDK 235

  Fly   310 SKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAV 374
            |:.|...:.|     :.|:.||..|...||:.|                                
Human   236 SEGRFHVQNL-----SQVEQDGRTGHGLRRSSK-------------------------------- 263

  Fly   375 DFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIAS 439
                                                                             
Human   264 ----------------------------------------------------------------- 263

  Fly   440 HLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLG 504
                             .||                                             
Human   264 -----------------FCL--------------------------------------------- 266

  Fly   505 GVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAV 569
                                   :|.||.:||.||.|.|.:||||||::.: :.:.::..|...|
Human   267 -----------------------KEHKALKTLGIIMGTFTLCWLPFFIVNI-VHVIQDNLIRKEV 307

  Fly   570 ASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRKAAARA 612
            ..|..|:||.||..||:|| ..:|:||.||:.:|..|:::.:|
Human   308 YILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELLCLRRSSLKA 349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 11/25 (44%)
TM helix 2 125..151 CDD:320454 12/25 (48%)
TM helix 3 163..193 CDD:320454 18/29 (62%)
TM helix 4 204..226 CDD:320454 5/22 (23%)
TM helix 5 247..276 CDD:320454 9/28 (32%)
7tm_GPCRs <525..599 CDD:475119 30/73 (41%)
TM helix 6 533..555 CDD:410628 12/21 (57%)
TM helix 7 567..592 CDD:410628 11/24 (46%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 71/201 (35%)
ADRB2NP_000015.2 7tmA_Beta2_AR 34..336 CDD:341355 114/513 (22%)
TM helix 1 35..61 CDD:341355 11/25 (44%)
TM helix 2 68..95 CDD:341355 12/26 (46%)
TM helix 3 106..136 CDD:341355 18/29 (62%)
TM helix 4 148..171 CDD:341355 5/22 (23%)
TM helix 5 196..228 CDD:341355 10/31 (32%)
TM helix 6 266..296 CDD:341355 16/98 (16%)
TM helix 7 305..330 CDD:341355 11/25 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..413
PDZ-binding 410..413
Blue background indicates that the domain is not in the aligned region.

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