DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and ADRA2C

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_000674.2 Gene:ADRA2C / 152 HGNCID:283 Length:462 Species:Homo sapiens


Alignment Length:530 Identity:155/530 - (29%)
Similarity:225/530 - (42%) Gaps:142/530 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 MAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWI 157
            :|.|:|.:|:.|::|||.|:.|::..|.|:...|..:.|||.||:.||.||||.....|:...|.
Human    54 LAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWY 118

  Fly   158 LGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVS 221
            .|...|.::.:.|||.||:||:||.||:.||||:||. ::||..||||||...|..||..:.::|
Human   119 FGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVIS 183

  Fly   222 LAPQFG-WKDPD---YMKRIEEQHCMVSQDVGYQIFATCC-TFYVPLLVILFLYWKIYIIARKRI 281
            ..|... ::.||   |      ..|.::.:..| |.::|. :|:.|.|::..:|.:||.:|:.|.
Human   184 FPPLVSLYRQPDGAAY------PQCGLNDETWY-ILSSCIGSFFAPCLIMGLVYARIYRVAKLRT 241

  Fly   282 QRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRI 346
            :         ||:|                           :|.||..||.....:         
Human   242 R---------TLSE---------------------------KRAPVGPDGASPTTE--------- 261

  Fly   347 CFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDAD 411
                |...|...||..|..|...|.:..|.:|.|..|.... .......:..||.|         
Human   262 ----NGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRR-GALRRGGRRRAGAE--------- 312

  Fly   412 DYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVA 476
                                                      ||.|                   
Human   313 ------------------------------------------GGAG------------------- 316

  Fly   477 GAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQ------- 534
            ||...|:|.|:.|.||.|..::.|.|.....||..:....|::||:...:...||.||       
Human   317 GADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFT 381

  Fly   535 -TLAIITGAFVICWLPFFVMALTMSLCKE-CEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRR 597
             .||::.|.||:||.|||.......:|:| |::...:...|.|:||.||:|||||||:||.:|||
Human   382 FVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRR 446

  Fly   598 AFKRILFGRK 607
            :||.|||.|:
Human   447 SFKHILFRRR 456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 10/24 (42%)
TM helix 2 125..151 CDD:320454 12/25 (48%)
TM helix 3 163..193 CDD:320454 16/29 (55%)
TM helix 4 204..226 CDD:320454 8/21 (38%)
TM helix 5 247..276 CDD:320454 9/29 (31%)
7tm_GPCRs <525..599 CDD:475119 35/82 (43%)
TM helix 6 533..555 CDD:410628 12/29 (41%)
TM helix 7 567..592 CDD:410628 13/24 (54%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 73/199 (37%)
ADRA2CNP_000674.2 7tmA_alpha2C_AR 60..448 CDD:320446 146/514 (28%)
TM helix 2 86..112 CDD:320446 12/25 (48%)
TM helix 3 124..154 CDD:320446 16/29 (55%)
TM helix 4 166..189 CDD:320446 8/22 (36%)
TM helix 5 207..236 CDD:320446 9/29 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..347 34/211 (16%)
TM helix 6 375..405 CDD:320446 10/29 (34%)
TM helix 7 416..441 CDD:320446 13/24 (54%)

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