DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and ADRA2A

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_000672.3 Gene:ADRA2A / 150 HGNCID:281 Length:465 Species:Homo sapiens


Alignment Length:536 Identity:152/536 - (28%)
Similarity:220/536 - (41%) Gaps:151/536 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 IAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG 155
            :.:..:.||::|:|:.|||.||.|:...|.|:...|..:.|||.||:.||.||:|.....|:...
Human    49 LTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY 113

  Fly   156 WILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALI 219
            |..|...|:|:.:.|||.||:||:||.||:.||||::|. |:||..|||||:..:|..||..:.:
Human   114 WYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAV 178

  Fly   220 VSLAPQF--------GWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYII 276
            :|..|..        |...|      .|..|.::....|.|.:...:|:.|.|:::.:|.:||.|
Human   179 ISFPPLISIEKKGGGGGPQP------AEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQI 237

  Fly   277 ARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAG--ERTPVDGDGTGGQLQRR 339
            |::|                        .:...|:|..:......|  ||.|   :|.|.:..  
Human   238 AKRR------------------------TRVPPSRRGPDAVAAPPGGTERRP---NGLGPERS-- 273

  Fly   340 TRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELT 404
                               ||..||.|..:               .|:.:.:. ...:.||..  
Human   274 -------------------AGPGGAEAEPL---------------PTQLNGAP-GEPAPAGPR-- 301

  Fly   405 TVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPS---- 465
              .:||.|...|::::         ||.:                             .|.    
Human   302 --DTDALDLEESSSSD---------HAER-----------------------------PPGPRRP 326

  Fly   466 EKALSGAGTV-AGAVAGGSG---SGSGEEGAGTEGKNAGVG---LGGVLASIANPHQKLAKRRQL 523
            |:...|.|.. |..|..|..   .|.|..|.||..  ||.|   :|...||.....|        
Human   327 ERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPA--AGPGEERVGAAKASRWRGRQ-------- 381

  Fly   524 LEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSL-CKECEIHTAVASLFLWLGYFNSTLNPVI 587
               .||::....||::.|.||:||.|||   .|.:| ...|.:...:...|.|.||.||:|||||
Human   382 ---NREKRFTFVLAVVIGVFVVCWFPFF---FTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVI 440

  Fly   588 YTIFNPEFRRAFKRIL 603
            |||||.:||||||:||
Human   441 YTIFNHDFRRAFKKIL 456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 10/25 (40%)
TM helix 2 125..151 CDD:320454 11/25 (44%)
TM helix 3 163..193 CDD:320454 17/29 (59%)
TM helix 4 204..226 CDD:320454 7/21 (33%)
TM helix 5 247..276 CDD:320454 8/28 (29%)
7tm_GPCRs <525..599 CDD:475119 34/74 (46%)
TM helix 6 533..555 CDD:410628 10/21 (48%)
TM helix 7 567..592 CDD:410628 14/24 (58%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 72/204 (35%)
ADRA2ANP_000672.3 7tmA_alpha2A_AR 49..452 CDD:320445 147/530 (28%)
TM helix 1 50..76 CDD:320445 10/25 (40%)
TM helix 2 83..109 CDD:320445 11/25 (44%)
TM helix 3 121..151 CDD:320445 17/29 (59%)
TM helix 4 163..186 CDD:320445 7/22 (32%)
TM helix 5 208..237 CDD:320445 8/28 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..368 37/209 (18%)
PHA03307 244..>389 CDD:223039 43/239 (18%)
TM helix 6 382..412 CDD:320445 13/32 (41%)
TM helix 7 420..445 CDD:320445 14/24 (58%)

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