DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and ADRA1D

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_000669.1 Gene:ADRA1D / 146 HGNCID:280 Length:572 Species:Homo sapiens


Alignment Length:558 Identity:140/558 - (25%)
Similarity:210/558 - (37%) Gaps:217/558 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 NRSING-----------NGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFV 111
            |||..|           ||.:....||...|.            :.:.|.|...||:.:.||:.|
Human    65 NRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQG------------VGVGVFLAAFILMAVAGNLLV 117

  Fly   112 IAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTA 176
            |.::...|:||.|.||.:.:||||||.::..|:|..|..|:...|..|...||:|.:.|||||||
Human   118 ILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTA 182

  Fly   177 SILHLVAIAADRYWTVT-NIDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQ 240
            |||.|..|:.|||..|. ::.|..:.|.|:...::..:|..||:||:.|..|||:|   ...:|:
Human   183 SILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEP---VPPDER 244

  Fly   241 HCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVREL 305
            .|.::::.||.:|::.|:||:|:.||:.:|.::|::||.              |....::.|   
Human   245 FCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARS--------------TTRSLEAGV--- 292

  Fly   306 KKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMA 370
            |:||.|......|:.                          |.|..|       |::||      
Human   293 KRERGKASEVVLRIH--------------------------CRGAAT-------GADGA------ 318

  Fly   371 AIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHH 435
                                  :..:|..|                                  |
Human   319 ----------------------HGMRSAKG----------------------------------H 327

  Fly   436 LIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAG 500
            ...|.|:.                                                         
Human   328 TFRSSLSV--------------------------------------------------------- 335

  Fly   501 VGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEI 565
                                 :||:..||:|||:||||:.|.||:||.|||.:....||..:.:.
Human   336 ---------------------RLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKP 379

  Fly   566 HTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            ...|..:..|||||||.:||:||...:.||:|||.|:|
Human   380 SEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLL 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 8/25 (32%)
TM helix 2 125..151 CDD:320454 11/25 (44%)
TM helix 3 163..193 CDD:320454 18/29 (62%)
TM helix 4 204..226 CDD:320454 7/21 (33%)
TM helix 5 247..276 CDD:320454 11/28 (39%)
7tm_GPCRs <525..599 CDD:475119 34/73 (47%)
TM helix 6 533..555 CDD:410628 13/21 (62%)
TM helix 7 567..592 CDD:410628 12/24 (50%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 73/196 (37%)
ADRA1DNP_000669.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..77 4/11 (36%)
7tmA_alpha1D_AR 97..413 CDD:320450 127/508 (25%)
TM helix 1 98..124 CDD:320450 8/25 (32%)
TM helix 2 131..157 CDD:320450 11/25 (44%)
TM helix 3 169..199 CDD:320450 18/29 (62%)
TM helix 4 211..234 CDD:320450 7/22 (32%)
TM helix 5 251..280 CDD:320450 11/28 (39%)
TM helix 6 341..371 CDD:320450 17/29 (59%)
TM helix 7 381..406 CDD:320450 12/24 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..488
Blue background indicates that the domain is not in the aligned region.

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