DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and ADORA2A

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_000666.2 Gene:ADORA2A / 135 HGNCID:263 Length:412 Species:Homo sapiens


Alignment Length:536 Identity:112/536 - (20%)
Similarity:159/536 - (29%) Gaps:263/536 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 IAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG 155
            :.:.|.|.:.:| .|:|||.|..|:.|..|||||.||.|.|||.||:.|..|.:|....  ||.|
Human     8 VYITVELAIAVL-AILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTG 69

  Fly   156 WILGPELCDIWTSCDVLCCT-ASILHLVAIAADRYWTV-TNIDYNNLRTPRRVFLMIFCVWFAAL 218
            :......| ::.:|.||..| :||..|:|||.|||..: ..:.||.|.|..|...:|...|..:.
Human    70 FCAACHGC-LFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSF 133

  Fly   219 IVSLAPQFGWKDPDYMK--RIEEQHC------MVSQDV---GYQI---FATCCTFYVPLLVILFL 269
            .:.|.|..||.:....|  :...|.|      .:.:||   .|.:   |..|  ..||||::|.:
Human   134 AIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC--VLVPLLLMLGV 196

  Fly   270 YWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGG 334
            |.:|::.||                        |:||:..|:                       
Human   197 YLRIFLAAR------------------------RQLKQMESQ----------------------- 214

  Fly   335 QLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHA 399
                                                                             
Human   215 ----------------------------------------------------------------- 214

  Fly   400 GTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTP 464
                                                          ||                |
Human   215 ----------------------------------------------PL----------------P 217

  Fly   465 SEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRE 529
            .|:|.|                                                      ..::|
Human   218 GERARS------------------------------------------------------TLQKE 228

  Fly   530 RKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYF-------NSTLNPVI 587
            ..||::||||.|.|.:||||..::......|.:|. |..     |||.|.       ||.:||.|
Human   229 VHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCS-HAP-----LWLMYLAIVLSHTNSVVNPFI 287

  Fly   588 YTIFNPEFRRAFKRIL 603
            |.....|||:.|::|:
Human   288 YAYRIREFRQTFRKII 303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 9/25 (36%)
TM helix 2 125..151 CDD:320454 11/25 (44%)
TM helix 3 163..193 CDD:320454 14/31 (45%)
TM helix 4 204..226 CDD:320454 5/21 (24%)
TM helix 5 247..276 CDD:320454 12/34 (35%)
7tm_GPCRs <525..599 CDD:475119 29/80 (36%)
TM helix 6 533..555 CDD:410628 11/21 (52%)
TM helix 7 567..592 CDD:410628 10/31 (32%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 71/211 (34%)
ADORA2ANP_000666.2 7tmA_Adenosine_R_A2A 7..299 CDD:320196 110/530 (21%)
TM helix 1 8..34 CDD:320196 9/26 (35%)
TM helix 2 41..68 CDD:320196 12/28 (43%)
TM helix 3 77..107 CDD:320196 14/30 (47%)
TM helix 4 121..139 CDD:320196 3/17 (18%)
TM helix 5 174..204 CDD:320196 10/31 (32%)
TM helix 6 226..256 CDD:320196 13/29 (45%)
TM helix 7 267..292 CDD:320196 10/24 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 391..412
Blue background indicates that the domain is not in the aligned region.

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