DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and Drd5

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_038531.1 Gene:Drd5 / 13492 MGIID:94927 Length:478 Species:Mus musculus


Alignment Length:546 Identity:120/546 - (21%)
Similarity:183/546 - (33%) Gaps:249/546 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 IAMAVVLGLMILVTIIGNVFVIAAIILERNLQ-NVANYLVASLAVADLFVACLVMPLGAVYEISN 154
            :..|.:|.|:|:.|::|||.|.|||:..|:|: .:.|..:.||||:|||||.||||..||.|::.
Mouse    39 VVTAGLLTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAG 103

  Fly   155 GWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAAL 218
            .|..| ..||||.:.|::|.|||||:|..|:.||||.::. ..|....|.|...:|:...|..::
Mouse   104 YWPFG-AFCDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYERKMTQRVALVMVALAWTLSI 167

  Fly   219 IVSLAP-QFGWKDPDYMKRIEE-------------------QHCMVSQDVGYQIFATCCTFYVPL 263
            ::|..| |..|.......:..|                   ::|..|.:..|.|.::..:||:|:
Mouse   168 LISFIPVQLNWHRDKAGSQGREGLLSNETPWEEGWELDGRTENCDSSLNRTYAISSSLISFYIPV 232

  Fly   264 LVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVD 328
            .:::..|.:||.||:.:|:|                                             
Mouse   233 AIMIVTYTRIYRIAQVQIRR--------------------------------------------- 252

  Fly   329 GDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNY 393
                                                                             
Mouse   253 ----------------------------------------------------------------- 252

  Fly   394 DNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGC 458
                        :||                   :..|.:|             |||....| .|
Mouse   253 ------------ISS-------------------LERAAEH-------------AQSCRSRG-AC 272

  Fly   459 LTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQL 523
              ...||.:|                                                       
Mouse   273 --EPDPSLRA------------------------------------------------------- 280

  Fly   524 LEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKE-----------CEIHTAVASLFLWLG 577
             ..|:|.|..:||::|.|.||.||||||::...:..|..           |...|.. .:|:|.|
Mouse   281 -SIKKETKVFKTLSVIMGVFVCCWLPFFILNCMVPFCSSGDAQGPRTGFPCVSETTF-DIFVWFG 343

  Fly   578 YFNSTLNPVIYTIFNPEFRRAFKRIL 603
            :.||:|||:||. ||.:||:.|.::|
Mouse   344 WANSSLNPIIYA-FNADFRKVFAQLL 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 12/25 (48%)
TM helix 2 125..151 CDD:320454 16/25 (64%)
TM helix 3 163..193 CDD:320454 17/29 (59%)
TM helix 4 204..226 CDD:320454 5/22 (23%)
TM helix 5 247..276 CDD:320454 8/28 (29%)
7tm_GPCRs <525..599 CDD:475119 32/84 (38%)
TM helix 6 533..555 CDD:410628 12/21 (57%)
TM helix 7 567..592 CDD:410628 11/24 (46%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 74/217 (34%)
Drd5NP_038531.1 7tm_GPCRs 39..364 CDD:475119 118/540 (22%)
TM helix 1 41..65 CDD:410628 12/23 (52%)
TM helix 2 75..97 CDD:410628 14/21 (67%)
TM helix 3 112..134 CDD:410628 12/21 (57%)
TM helix 4 157..173 CDD:410628 3/15 (20%)
TM helix 5 217..240 CDD:410628 5/22 (23%)
TM helix 6 289..311 CDD:410628 12/21 (57%)
TM helix 7 333..358 CDD:410628 12/26 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 416..446
Blue background indicates that the domain is not in the aligned region.

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