Protein Alignment 5-HT1B and Drd3

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_006521840.1
• Gene: Drd3 / 13490
• MGIID: 94925
• Length: 478
• Species: Mus musculus
• Alignment Length: 528
• Identity: 149/528 - (28%)
• Similarity: 211/528 - (39%)
• Gaps: 146/528 - (27%)

  Fly   100 MILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG-WILGPELC 163
            :||..|.||..|.||::.||.||...||||.|||||||.||.||||.....|::.| |......|
Mouse    71 LILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICC 135

  Fly   164 DIWTSCDVLCCTASILHLVAIAADRYWTVT-NIDYNN---LRTPRRVFLMIFCVWFAALIVSLAP 224
            |::.:.||:.||||||:|.||:.|||..|. .:.|.:   ..:.|||.|||..||..|..||...
Mouse   136 DVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPL 200

  Fly   225 QFGWK---DPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQ 286
            .||:.   ||..        |.:| :..:.|:::..:||||..|.:.:|.:||::.|:|.::|.
Mouse   201 LFGFNTTGDPSI--------CSIS-NPDFVIYSSVVSFYVPFGVTVLVYARIYMVLRQRRRKRI- 255

  Fly   287 KSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRN 351
                :|...:.|.|......::.|..|....|                |...|.|
Mouse   256 ----LTRQNSQCISIRPGFPQQSSCLRLHPIR----------------QFSIRAR---------- 290

  Fly   352 TNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTS 416
                                    |.|.| |.:........|..|
Mouse   291 ------------------------FLSDA-TGQMEHIEDKPYPQK-------------------- 310

  Fly   417 NANEIITLSQQVAHATQHHLIASHLNAITP------------LAQSIAMGGVGCLTTTTPSEKAL 469
                           .|..|: |||..::|            :.|..|:        ..|:
Mouse   311 ---------------CQDPLL-SHLQPLSPGQTHGELKRYYSICQDTAL--------RHPN---- 347

  Fly   470 SGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAK----RER 530
                     ..||.|....|....:........|...:..::|.....:.:...|:.:    ||:
Mouse   348 ---------FEGGGGMSQVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREK 403

  Fly   531 KAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEF 595
            ||.|.:.|:.|||::||||||:..:..:.|:.|.:...:.....||||.||.|||||||.||.||
Mouse   404 KATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNIEF 468

  Fly   596 RRAFKRIL 603
            |:||.:||
Mouse   469 RKAFLKIL 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	8/17 (47%)
		TM helix 2	125..151	CDD:320454	17/25 (68%)
		TM helix 3	163..193	CDD:320454	16/29 (55%)
		TM helix 4	204..226	CDD:320454	11/21 (52%)
		TM helix 5	247..276	CDD:320454	9/28 (32%)
		7tm_GPCRs	<525..599	CDD:475119	35/77 (45%)
		TM helix 6	533..555	CDD:410628	11/21 (52%)
		TM helix 7	567..592	CDD:410628	13/24 (54%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	79/194 (41%)
Drd3	XP_006521840.1	7tmA_D3_dopamine_R	62..472	CDD:320436	145/522 (28%)
		TM helix 1	63..89	CDD:320436	8/17 (47%)
		TM helix 2	96..119	CDD:320436	17/22 (77%)
		TM helix 3	135..165	CDD:320436	16/29 (55%)
		TM helix 4	182..200	CDD:320436	9/17 (53%)
		TM helix 5	217..242	CDD:320436	7/24 (29%)
		TM helix 6	400..430	CDD:320436	15/29 (52%)
		TM helix 7	440..465	CDD:320436	13/24 (54%)