Protein Alignment 5-HT1B and Drd1

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_034206.1
• Gene: Drd1 / 13488
• MGIID: 99578
• Length: 446
• Species: Mus musculus
• Alignment Length: 531
• Identity: 127/531 - (23%)
• Similarity: 191/531 - (35%)
• Gaps: 226/531 - (42%)

  Fly    91 IAMAVVLGLMILVTIIGNVFVIAAIILERNLQN-VANYLVASLAVADLFVACLVMPLGAVYEISN 154
            |..|..|.|:||.|::||..|.||:|..|:|:: |.|:.|.||||:||.||.||||..||.||:.
Mouse    23 ILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAG 87

  Fly   155 GWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAAL 218
            .|..| ..|:||.:.|::|.|||||:|..|:.||||.::: ..|....||:..|::|...|..::
Mouse    88 FWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSV 151

  Fly   219 IVSLAP-QFGWK--------DPDY--MKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWK 272
            ::|..| |..|.        |.::  ::..|:.:|.......|.|.::..:||:|:.:::..|..
Mouse   152 LISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTS 216

  Fly   273 IYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQ 337
            ||.||:|:|                                   :|:.|.||..|
Mouse   217 IYRIAQKQI-----------------------------------RRISALERAAV---------- 236

  Fly   338 RRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTE 402
                                                                             
Mouse   237 ----------------------------------------------------------------- 236

  Fly   403 LTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEK 467
                                       ||.                        .|.|||
Mouse   237 ---------------------------HAK------------------------NCQTTT----- 245

  Fly   468 ALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKA 532
                            |:|:..|.:.:|....                        :..|||.|.
Mouse   246 ----------------GNGNPVECSQSESSFK------------------------MSFKRETKV 270

  Fly   533 AQTLAIITGAFVICWLPFFVMALTMSLCKECE-----IHTAVASLFLWLGYFNSTLNPVIYTIFN 592
            .:||::|.|.||.||||||:....:..|...|     |.:....:|:|.|:.||:|||:||. ||
Mouse   271 LKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYA-FN 334

  Fly   593 PEFRRAFKRIL 603
            .:|::||..:|
Mouse   335 ADFQKAFSTLL 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	12/25 (48%)
		TM helix 2	125..151	CDD:320454	16/25 (64%)
		TM helix 3	163..193	CDD:320454	16/29 (55%)
		TM helix 4	204..226	CDD:320454	5/22 (23%)
		TM helix 5	247..276	CDD:320454	8/28 (29%)
		7tm_GPCRs	<525..599	CDD:475119	32/78 (41%)
		TM helix 6	533..555	CDD:410628	12/21 (57%)
		TM helix 7	567..592	CDD:410628	10/24 (42%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	77/208 (37%)
Drd1	NP_034206.1	7tm_GPCRs	22..341	CDD:475119	124/525 (24%)
		TM helix 1	25..49	CDD:410628	11/23 (48%)
		TM helix 2	59..81	CDD:410628	14/21 (67%)
		TM helix 3	96..118	CDD:410628	11/21 (52%)
		TM helix 4	141..157	CDD:410628	3/15 (20%)
		TM helix 5	192..215	CDD:410628	5/22 (23%)
		TM helix 6	271..293	CDD:410628	12/21 (57%)
		TM helix 7	310..335	CDD:410628	11/25 (44%)