Protein Alignment 5-HT1B and Dop2R

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_061499915.1
• Gene: Dop2R / 1274598
• VectorBaseID: AGAMI1_010373
• Length: 659
• Species: Anopheles gambiae
• Alignment Length: 683
• Identity: 204/683 - (29%)
• Similarity: 297/683 - (43%)
• Gaps: 167/683 - (24%)

  Fly     1 MLKTVTTAMAAGDDDV-----PA------------------SILEIELPAILLNE---SLFIELN 39
            ||..|::.:|:.|.|.     ||                  ||.|      ||.|   |:|...|
Mosquito    61 MLSNVSSNVASNDTDQYYADDPAPYNDSLESPISDSTDSRGSIFE------LLAEDIGSIFYNAN 119

  Fly    40 GNLTQLVDTTSNLSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVT 104
            |....  |||.    :..|.|:     |||..:...|.:.  ..:|.|        :|.|..::|
Mosquito   120 GTFGN--DTTG----LAVNCSL-----SNTTCIGPTEAKE--YHYWCL--------ILVLFPILT 163

  Fly   105 IIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG-WILGPELCDIWTS 168
            :.|||.||.|:..||.||.|.||.:.|||:|||.||.:|||. |||.:.|| |.|....||.:.:
Mosquito   164 LFGNVLVILAVCRERTLQTVTNYFIVSLAIADLLVAVVVMPF-AVYVLVNGAWTLPNFACDFYIA 227

  Fly   169 CDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGW---- 228
            .||:|.|:||.:||||:.|||..||. |.|...:..|||.|.|..||..:..:......|.
Mosquito   228 MDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCLTILLVWAISAAIGSPIVLGLNNTQ 292

  Fly   229 -KDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRI--QRRAQKSFN 290
             :.||.        | |..:..:.::::..:||:|.::::||||.|:...|.|.  ||.|:|..
Mosquito   293 DRSPDL--------C-VFYNTDFIVYSSLTSFYIPCIIMVFLYWNIFKALRTRAKKQRAARKPH- 347

  Fly   291 VTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRIC--FGRNTN 353
              |:|.....::.|       ..|:.|||   ..|.:||.         ||...:|.  ..|.||
Mosquito   348 --LSEITAGGSIIE-------NIAQTKRL---AETQLDGS---------TRSGSKILPDEERPTN 391

  Fly   354 TANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADD--YRTS 416
            ||   :||......:..:..:|...:.:..:.|||.             |.||..:|.:  :.||
Mosquito   392 TA---SGSNEEDDENAGSPDIDDCHVIVNDKSTEFM-------------LATVVEEAGNKSFSTS 440

  Fly   417 NANEI--ITLSQQVAHATQHHLIASHLNAITP--LAQSIAMGGVGCLTTTTPSEKALSGAGTVAG 477
            ..:.:  |..:|||.....    .:|.:...|  :|.::|      :..|.|....::....|..
Mosquito   441 TFSVVAQIATTQQVPSDPN----GNHDSGYAPSSIADALA------VNATPPESLNVTATVIVNK 495

  Fly   478 AVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASI-------------------------------- 510
            :....|.:||..:.|....|...:...||..::
Mosquito   496 SATIRSRNGSPRKEASVTLKPLSLVRCGVQQALTLNRNDSTLSTNSRDSSRKDKKNTQASRFTIY 560

  Fly   511 -ANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLC----KECEIHTAVA 570
             .|...|  |:|:...||:||||.:||||:.|.|:.||:|||...:..::|    |:|.....:.
Mosquito   561 KVNKASK--KKREKSSAKKERKATKTLAIVLGVFLFCWVPFFTCNIMDAMCAKLDKDCRPGVTIF 623

  Fly   571 SLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            :|..||||.||.:|||||||||||||:|||:|:
Mosquito   624 NLTTWLGYMNSFVNPVIYTIFNPEFRKAFKKIM 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	9/25 (36%)
		TM helix 2	125..151	CDD:320454	15/25 (60%)
		TM helix 3	163..193	CDD:320454	15/29 (52%)
		TM helix 4	204..226	CDD:320454	7/21 (33%)
		TM helix 5	247..276	CDD:320454	8/28 (29%)
		7tm_GPCRs	<525..599	CDD:475119	40/77 (52%)
		TM helix 6	533..555	CDD:410628	11/21 (52%)
		TM helix 7	567..592	CDD:410628	14/24 (58%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	78/204 (38%)
Dop2R	XP_061499915.1	None