Protein Alignment 5-HT1B and Oct-TyrR

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_061506991.1
• Gene: Oct-TyrR / 1273444
• VectorBaseID: AGAMI1_002266
• Length: 644
• Species: Anopheles gambiae
• Alignment Length: 664
• Identity: 199/664 - (29%)
• Similarity: 290/664 - (43%)
• Gaps: 144/664 - (21%)

  Fly    24 ELPAILLNESLF--IELNGNLTQLVDTTSNLSQIVWNRSINGNGNSNTFDLVDDEQER------- 79
            ||..:|.:|...  :.|.| ||..:...||...:..|...||:..|...|......:.
Mosquito    37 ELDILLRHEGSIPAVSLAG-LTATLGLDSNGELLGANYGANGSDLSELLDGCPKPDDTLYPTMFG 100

  Fly    80 --AAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACL 142
              .||..|   :.|..|::|.|:|::||:||:.||.::...:.|:.|.|:.:.|||||||.||.|
Mosquito   101 IDLAVPQW---EAIGTALILTLIIIITIVGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVAIL 162

  Fly   143 VMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRV 206
            |:||...|.:...|..|..:|.:|.:.||||||||||:|.|||.||||.:|: |:|...||..||
Mosquito   163 VLPLNVAYSLLGRWEFGIHVCKMWLTSDVLCCTASILNLCAIALDRYWAITDPINYAQKRTLERV 227

  Fly   207 FLMIFCVWFAALIVSLAPQFGWKD-PDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLY 270
            ..:|..||..:|::|..|..||.| |:...  .|..|.::.:.||.|:::..:|::||.::..:|
Mosquito   228 LALIAGVWVLSLVISSPPLIGWNDWPEEFS--SEFPCQLTSNQGYVIYSSLGSFFIPLAIMTIVY 290

  Fly   271 WKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKE--------------------------- 308
            .:|||..|:|::.|||.|...||............:||
Mosquito   291 IEIYIATRRRLRERAQASKINTLASRSIGMVAGNGEKELTTTHHQQQQQQQQHQHHHQSHHHQDG 355

  Fly   309 ----------RSKRRAERKRLEAGERTPV-DGDGT---------GGQLQR-------RTRKRMRI 346
                      .|:.....::.:.|...|| .|.|.         ||.|.|       |.||:..
Mosquito   356 HAIQHDQESISSETNNHNEQTDTGSGGPVLAGSGKPNKKGHLRFGGYLGRALGGAAGRHRKKQH- 419

  Fly   347 CFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDAD 411
             ..:.........|.:|...|        .|:.|:.:.|.:..|   ||..|:|      |.|:
Mosquito   420 -HRKRPGDGPAEEGEDGRPHR--------LAASALHQREDDSVT---DNPDHSG------SGDS- 465

  Fly   412 DYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVA 476
                         ...|..|.   |.|:|.:|:.|...:..|.|               |:.|..
Mosquito   466 -------------GGGVGKAP---LDAAHPSALLPPTGNCDMTG---------------GSATGE 499

  Fly   477 GAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKR-----------RQLLEAK--- 527
            .|...|:.:...:...|.....|.:   .|:|:.|.|..:|..|           .|.:|.|
Mosquito   500 PAPRNGASNNHHQREVGFHESTAEL---MVVAAAAPPTTRLGGRLKQSFRKPGGINQFIEEKQKI 561

  Fly   528 ---RERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYT 589
               :||:||:||.||.|.||:||||||:|.:.:..|..|.....:.:...||||.||.|||:|||
Mosquito   562 SLSKERRAARTLGIIMGVFVVCWLPFFLMYVILPFCPSCCPTNKLINFITWLGYINSALNPIIYT 626

  Fly   590 IFNPEFRRAFKRIL 603
            |||.::||||||:|
Mosquito   627 IFNLDYRRAFKRLL 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	10/25 (40%)
		TM helix 2	125..151	CDD:320454	14/25 (56%)
		TM helix 3	163..193	CDD:320454	20/29 (69%)
		TM helix 4	204..226	CDD:320454	8/21 (38%)
		TM helix 5	247..276	CDD:320454	9/28 (32%)
		7tm_GPCRs	<525..599	CDD:475119	39/79 (49%)
		TM helix 6	533..555	CDD:410628	15/21 (71%)
		TM helix 7	567..592	CDD:410628	13/24 (54%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	83/197 (42%)
Oct-TyrR	XP_061506991.1	None