Protein Alignment 5-HT1B and Octbeta2R

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_003436280.1
• Gene: Octbeta2R / 1273081
• VectorBaseID: AGAMI1_002356
• Length: 526
• Species: Anopheles gambiae
• Alignment Length: 537
• Identity: 133/537 - (24%)
• Similarity: 203/537 - (37%)
• Gaps: 185/537 - (34%)

  Fly    72 LVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVAD 136
            :||...:....|:..:|.::..|.::..:|:..|.||:.||.::...|.|:.:.||.|.|||:||
Mosquito   114 IVDGGIDAGGGEWIDVVLLVLKASIMMFIIVAAIFGNLLVIISVKRHRKLRVITNYFVVSLAMAD 178

  Fly   137 LFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNL 200
            :.||.:.|......:|:..|..|..:||:|.|.||...|||||||..|:.|||:.:.. :.|...
Mosquito   179 IMVAMMAMTFNFSVQITGSWKFGSFMCDVWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPIS 243

  Fly   201 RTPRRVFLMIFCVWFAALIVSLAPQF-GWKDPDYMKR---IEEQHCMVSQDVGYQIFATCCTFYV 261
            .|.|.|.:|:...|.:..::|..|.| ||...:..|:   .....|:...:..|.:.::..:|::
Mosquito   244 MTKRVVAIMLLNTWISPALLSFVPIFAGWYTTEKHKQEVLDNPDSCLFIVNKPYAVISSSISFFI 308

  Fly   262 PLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTP 326
            |..:::|.|::|:                                  |...|.|::
Mosquito   309 PCTIMVFTYFQIF----------------------------------REANRQEKQ--------- 330

  Fly   327 VDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTS 391
                                                                ||:.:
Mosquito   331 ----------------------------------------------------LALRQ-------- 335

  Fly   392 NYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGV 456
                    ||.:                        :.|  ||:                ..|||
Mosquito   336 --------GTAM------------------------LMH--QHN----------------TGGGV 350

  Fly   457 GCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRR 521
            |                      .||||.|:..|.....|.:..:.|..|     :..|...|.|
Mosquito   351 G----------------------GGGSGGGTNGEALSGSGSSKTLTLHEV-----DAEQTPTKDR 388

  Fly   522 QLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPV 586
            .|::.|||.|||:||.||.|.|::||||||:..:..|||..|.....|.:|..|:|||||||||:
Mosquito   389 HLIKMKREHKAARTLGIIMGTFILCWLPFFLWYIITSLCDRCPNPDIVVALVFWIGYFNSTLNPL 453

  Fly   587 IYTIFNPEFRRAFKRIL 603
            ||..||.:||.||:..|
Mosquito   454 IYAYFNRDFREAFRNTL 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	7/25 (28%)
		TM helix 2	125..151	CDD:320454	11/25 (44%)
		TM helix 3	163..193	CDD:320454	17/29 (59%)
		TM helix 4	204..226	CDD:320454	6/21 (29%)
		TM helix 5	247..276	CDD:320454	6/28 (21%)
		7tm_GPCRs	<525..599	CDD:475119	40/73 (55%)
		TM helix 6	533..555	CDD:410628	13/21 (62%)
		TM helix 7	567..592	CDD:410628	14/24 (58%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	59/200 (30%)
Octbeta2R	XP_003436280.1	7tmA_DmOct-betaAR-like	134..466	CDD:320194	126/511 (25%)
		TM helix 1	134..160	CDD:320194	7/25 (28%)
		TM helix 2	167..193	CDD:320194	11/25 (44%)
		TM helix 3	205..235	CDD:320194	17/29 (59%)
		TM helix 4	247..270	CDD:320194	6/22 (27%)
		TM helix 5	294..323	CDD:320194	6/62 (10%)
		TM helix 6	394..424	CDD:320194	18/29 (62%)
		TM helix 7	434..459	CDD:320194	14/24 (58%)