Protein Alignment 5-HT1B and Oamb

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_061508856.1
• Gene: Oamb / 1272230
• VectorBaseID: AGAMI1_010906
• Length: 592
• Species: Anopheles gambiae
• Alignment Length: 619
• Identity: 174/619 - (28%)
• Similarity: 269/619 - (43%)
• Gaps: 171/619 - (27%)

  Fly    80 AAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVM 144
            |:|::.....::::||:..:.:|| |:||..||||::....|::|.|:.:.|||||||.|...|:
Mosquito    11 ASVQWTDPTNLVSLAVLAFINVLV-IVGNCLVIAAVLCSHKLRSVTNFFIVSLAVADLLVGLAVL 74

  Fly   145 PLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFL 208
            |..|.:|:...||.|...|.||.:.||..||||||:|.||:.|||..||. :.|.::.:.||...
Mosquito    75 PFSATWEVFKVWIFGDVWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTRRAKS 139

  Fly   209 MIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQH---------------------CMVSQDVGYQI 252
            :|..:|..:.::...|..|||:....:.:..|:                     |.::.|.||.:
Mosquito   140 LIAGLWVLSFVICFPPLVGWKEQKVKENVYYQYGNYTLVSVTPSPAPPLPCPWTCELTNDAGYVV 204

  Fly   253 FATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERK 317
            ::...:||:|:.|:||.||:|| .|..|..|...:.|..|
Mosquito   205 YSALGSFYIPMFVMLFFYWRIY-RAAVRTTRAINQGFRTT------------------------- 243

  Fly   318 RLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAIT 382
                        .|.|.:.. ..|..:||..||.:.:|.:
Mosquito   244 ------------KGMGNRFD-DNRLTLRIHRGRGSTSAPL------------------------- 270

  Fly   383 REETEFSTSNYDNKSHAGTELTTVSSDADD--YRTSNANEIITLSQQVAHATQHH---LIASHLN 442
             .|:..|    :..:|:.|  |::.|.:.:  .|.|...:::.....|.|.|.||   .|:....
Mosquito   271 -HESPHS----NGSTHSTT--TSIGSASPERLSRYSTRGKLVGHGGTVPHPTAHHEKIKISVSYP 328

  Fly   443 AITPLAQSI-AMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTE----------- 495
            :...:|||. |..|.|      ||..|::.||.:|.:.:...|.|||    ||:
Mosquito   329 STENVAQSCHAEAGGG------PSSPAVAAAGAMATSSSSTGGGGSG----GTKLLYAVHYSSAN 383

  Fly   496 GKNAGVG-----------LGGVL---------------------------ASIANPH--QKLAKR 520
            |:::...           :|.||                           :|..:|.  :::.||
Mosquito   384 GRDSNASQIFRRPSKEQQMGSVLGGSTQYLTVSEQQQQQQQQQQSHRERGSSFLSPRASKRMGKR 448

  Fly   521 RQLLEAKR---ERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNST 582
            ....:.||   |.|||:|||||.|.||:||||||.|.|....|.:| |:..:.|:..|:||.||.
Mosquito   449 NIKAQVKRFRMETKAAKTLAIIVGLFVLCWLPFFTMYLVRPFCDDC-INELLFSIVFWIGYCNSA 512

  Fly   583 LNPVIYTIFNPEFRRAFKRILF------GRKAAA 610
            :||:||.:|:.:||.|||||:.      ||.|.|
Mosquito   513 INPMIYALFSKDFRFAFKRIICRCFCSGGRFAGA 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	11/25 (44%)
		TM helix 2	125..151	CDD:320454	12/25 (48%)
		TM helix 3	163..193	CDD:320454	17/29 (59%)
		TM helix 4	204..226	CDD:320454	5/21 (24%)
		TM helix 5	247..276	CDD:320454	13/28 (46%)
		7tm_GPCRs	<525..599	CDD:475119	38/76 (50%)
		TM helix 6	533..555	CDD:410628	16/21 (76%)
		TM helix 7	567..592	CDD:410628	10/24 (42%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	75/217 (35%)
Oamb	XP_061508856.1	None