DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and Adra2c

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_031444.2 Gene:Adra2c / 11553 MGIID:87936 Length:458 Species:Mus musculus


Alignment Length:561 Identity:155/561 - (27%)
Similarity:235/561 - (41%) Gaps:154/561 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 GNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANY 127
            |..|::..|.|....:.:|      ..:..:|.|:|.:|:.|::|||.|:.|::..|.|:...|.
Mouse    30 GGANASGTDWVPPPGQYSA------GAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNL 88

  Fly   128 LVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTV 192
            .:.|||.||:.||.||||.....|:...|..|...|.::.:.|||.||:||:||.||:.||||:|
Mouse    89 FLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSV 153

  Fly   193 TN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFG-WKDPD---YMKRIEEQHCMVSQDVGYQI 252
            |. ::||..||||||...|..||..:.::|..|... ::.||   |      ..|.::.:..| |
Mouse   154 TQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAY------PQCGLNDETWY-I 211

  Fly   253 FATCC-TFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAER 316
            .::|. :|:.|.|::..:|.:||.:|:.|.:         ||:|                     
Mouse   212 LSSCIGSFFAPCLIMGLVYARIYRVAKLRTR---------TLSE--------------------- 246

  Fly   317 KRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAI 381
                  :|.|...||.....:               |.....||..|..|.....:..|.:|.| 
Mouse   247 ------KRGPAGPDGASPTTE---------------NGLGKAAGENGHCAPPRTEVEPDESSAA- 289

  Fly   382 TREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITP 446
                        :.:...|                                              
Mouse   290 ------------ERRRRRG---------------------------------------------- 296

  Fly   447 LAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSG-SGEEGAGTEGKNAGVGLGGVLASI 510
               ::..||           :...||....|: |.|.|.| :.|:||.|..::.|.|.....||.
Mouse   297 ---ALRRGG-----------RRREGAEGDTGS-ADGPGPGLAAEQGARTASRSPGPGGRLSRASS 346

  Fly   511 ANPHQKLAKRRQLLEAKRERKAAQ--------TLAIITGAFVICWLPFFVMALTMSLCKE-CEIH 566
            .:....|::||:...:...||.||        .||::.|.||:||.|||.......:|:| |::.
Mouse   347 RSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLP 411

  Fly   567 TAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRK 607
            ..:...|.|:||.||:|||||||:||.:|||:||.|||.|:
Mouse   412 EPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRR 452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 10/25 (40%)
TM helix 2 125..151 CDD:320454 12/25 (48%)
TM helix 3 163..193 CDD:320454 16/29 (55%)
TM helix 4 204..226 CDD:320454 8/21 (38%)
TM helix 5 247..276 CDD:320454 9/29 (31%)
7tm_GPCRs <525..599 CDD:475119 35/82 (43%)
TM helix 6 533..555 CDD:410628 12/29 (41%)
TM helix 7 567..592 CDD:410628 13/24 (54%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 73/201 (36%)
Adra2cNP_031444.2 7tmA_alpha2C_AR 60..444 CDD:320446 141/515 (27%)
TM helix 2 86..112 CDD:320446 12/25 (48%)
TM helix 3 124..154 CDD:320446 16/29 (55%)
TM helix 4 166..189 CDD:320446 8/22 (36%)
TM helix 5 207..236 CDD:320446 9/29 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 245..343 29/213 (14%)
TM helix 6 371..401 CDD:320446 10/29 (34%)
TM helix 7 412..437 CDD:320446 13/24 (54%)

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