Protein Alignment 5-HT1B and Adra2a

DIOPT Version :9

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_031443.4
• Gene: Adra2a / 11551
• MGIID: 87934
• Length: 465
• Species: Mus musculus
• Alignment Length: 533
• Identity: 151/533 - (28%)
• Similarity: 218/533 - (40%)
• Gaps: 145/533 - (27%)

  Fly    91 IAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG 155
            :.:..:.||::|.|:.|||.||.|:...|.|:...|..:.|||.||:.||.||:|.....|:...
Mouse    49 LTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY 113

  Fly   156 WILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALI 219
            |..|...|:|:.:.|||.||:||:||.||:.||||::|. |:||..|||||:..:|..||..:.:
Mouse   114 WYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAV 178

  Fly   220 VSLAPQF--------GWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYII 276
            :|..|..        |.:.|      .|..|.::....|.|.::..:|:.|.|:::.:|.:||.|
Mouse   179 ISFPPLISIEKKGAGGGQQP------AEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQI 237

  Fly   277 ARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTR 341
            |::                                    |.|:....|.|.......|...||..
Mouse   238 AKR------------------------------------RTRVPPSRRGPDACSAPPGGADRRPN 266

  Fly   342 KRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTV 406
                   |......   ||..||.|..:               .|:.:.:. ...:.||..
Mouse   267 -------GLGPERG---AGPTGAEAEPL---------------PTQLNGAP-GEPAPAGPR---- 301

  Fly   407 SSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSG 471
            ..||.|...|:::|         ||.:           .|..:....|         |..|..:.
Mouse   302 DGDALDLEESSSSE---------HAER-----------PPGPRRPDRG---------PRAKGKTR 337

  Fly   472 AGTV-----------AGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLE 525
            |..|           ..|..|.||||.|||..           ||..||.....|
Mouse   338 ASQVKPGDSLPRRGPGAAGPGASGSGHGEERG-----------GGAKASRWRGRQ---------- 381

  Fly   526 AKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTI 590
             .||::....||::.|.||:||.|||.....:::  .|.:.:.:.:.|.|.||.||:||||||||
Mouse   382 -NREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAV--GCPVPSQLFNFFFWFGYCNSSLNPVIYTI 443

  Fly   591 FNPEFRRAFKRIL 603
            ||.:||||||:||
Mouse   444 FNHDFRRAFKKIL 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	67/189 (35%)
Adra2a	NP_031443.4	7tmA_alpha2A_AR	49..452	CDD:320445	146/527 (28%)
		TM helix 1	51..75	CDD:320445	10/23 (43%)
		TM helix 2	84..106	CDD:320445	11/21 (52%)
		TM helix 3	122..144	CDD:320445	12/21 (57%)
		TM helix 4	167..183	CDD:320445	4/15 (27%)
		TM helix 5	209..232	CDD:320445	5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..378		41/205 (20%)
		TM helix 6	388..410	CDD:320445	10/21 (48%)
		TM helix 7	420..445	CDD:320445	14/24 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940