Protein Alignment 5-HT1B and Adra1d

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_038488.4
• Gene: Adra1d / 11550
• MGIID: 106673
• Length: 562
• Species: Mus musculus
• Alignment Length: 529
• Identity: 134/529 - (25%)
• Similarity: 208/529 - (39%)
• Gaps: 199/529 - (37%)

  Fly    91 IAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG 155
            :.:.|.|...||..:.||:.||.::...|:||.|.||.:.:||||||.::..|:|..|..|:...
Mouse    91 VGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGF 155

  Fly   156 WILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVT-NIDYNNLRTPRRVFLMIFCVWFAALI 219
            |..|...||:|.:.||||||||||.|..|:.|||..|. ::.|..:.|.|:...::..:|..||:
Mouse   156 WAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALV 220

  Fly   220 VSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRR 284
            ||:.|..|||:|   ...:|:.|.::::|||.||::.|:||:|:.||:.:|.::|::|
Mouse   221 VSVGPLLGWKEP---VPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVA------- 275

  Fly   285 AQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAG-ERTPVDGDGTGGQLQRRTRKRMRICF 348
                                        |:..:.|||| :|.|    |...::..|..     |.
Mouse   276 ----------------------------RSTTRSLEAGIKREP----GKASEVVLRIH-----CR 303

  Fly   349 GRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDY 413
            |..|:.                                         |.:.||:
Mouse   304 GAATSA-----------------------------------------KGNPGTQ----------- 316

  Fly   414 RTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGA 478
                             :::.|.:.|.|:.
Mouse   317 -----------------SSKGHTLRSSLSV----------------------------------- 329

  Fly   479 VAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAF 543
                                                       :||:..||:|||:||||:.|.|
Mouse   330 -------------------------------------------RLLKFSREKKAAKTLAIVVGVF 351

  Fly   544 VICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRKA 608
            |:||.|||.:....||..:.:....|..:..|||||||.:||:||...:.||:|||.|:|   :.
Mouse   352 VLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLL---RC 413

  Fly   609 AARARSAKI 617
            ..|.|..::
Mouse   414 QCRRRRRRL 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	8/25 (32%)
		TM helix 2	125..151	CDD:320454	11/25 (44%)
		TM helix 3	163..193	CDD:320454	18/29 (62%)
		TM helix 4	204..226	CDD:320454	7/21 (33%)
		TM helix 5	247..276	CDD:320454	13/28 (46%)
		7tm_GPCRs	<525..599	CDD:475119	34/73 (47%)
		TM helix 6	533..555	CDD:410628	13/21 (62%)
		TM helix 7	567..592	CDD:410628	12/24 (50%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	74/196 (38%)
Adra1d	NP_038488.4	7tm_GPCRs	91..407	CDD:475119	128/509 (25%)
		TM helix 1	93..117	CDD:410628	8/23 (35%)
		TM helix 2	126..148	CDD:410628	10/21 (48%)
		TM helix 3	164..186	CDD:410628	14/21 (67%)
		TM helix 4	209..225	CDD:410628	5/15 (33%)
		TM helix 5	246..269	CDD:410628	11/22 (50%)
		TM helix 6	341..363	CDD:410628	13/21 (62%)
		TM helix 7	375..400	CDD:410628	12/24 (50%)