DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and Adra1b

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_031442.2 Gene:Adra1b / 11548 MGIID:104774 Length:515 Species:Mus musculus


Alignment Length:558 Identity:146/558 - (26%)
Similarity:217/558 - (38%) Gaps:214/558 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 NGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVAN 126
            |...:::|...:|            :.:.|::.:|||..||..|:||:.||.::...|:|:...|
Mouse    29 NQTSSNSTLPQLD------------VTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTN 81

  Fly   127 YLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWT 191
            |.:.:||:|||.::..|:|..|..|:...|:||...||||.:.||||||||||.|.||:.|||..
Mouse    82 YFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIG 146

  Fly   192 VT-NIDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFAT 255
            |. ::.|..|.|.|:..|.:..||..:.::|:.|..|||:|   ...:::.|.|:::..|.:|::
Mouse   147 VRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEP---APNDDKECGVTEEPFYALFSS 208

  Fly   256 CCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLE 320
            ..:||:||.|||.:|.::||:|::                                   ..|.||
Mouse   209 LGSFYIPLAVILVMYCRVYIVAKR-----------------------------------TTKNLE 238

  Fly   321 AGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREE 385
            ||                                          |.:.|                
Mouse   239 AG------------------------------------------VMKEM---------------- 245

  Fly   386 TEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQS 450
                                          ||:.| :||.   .|:...|               
Mouse   246 ------------------------------SNSKE-LTLR---IHSKNFH--------------- 261

  Fly   451 IAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQ 515
                           |..||                      .|:.|.            .||..
Mouse   262 ---------------EDTLS----------------------STKAKG------------HNPRS 277

  Fly   516 KLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFN 580
            .:|.:  |.:..||:|||:||.|:.|.|::||||||:.....||....:...||..:..||||||
Mouse   278 SIAVK--LFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFN 340

  Fly   581 STLNPVIYTIFNPEFRRAFKRIL-----FGRKAAARAR 613
            |.|||:||...:.||:|||.|||     .||:...|.|
Mouse   341 SCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRR 378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 10/25 (40%)
TM helix 2 125..151 CDD:320454 10/25 (40%)
TM helix 3 163..193 CDD:320454 20/29 (69%)
TM helix 4 204..226 CDD:320454 6/21 (29%)
TM helix 5 247..276 CDD:320454 11/28 (39%)
7tm_GPCRs <525..599 CDD:475119 35/73 (48%)
TM helix 6 533..555 CDD:410628 12/21 (57%)
TM helix 7 567..592 CDD:410628 14/24 (58%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 76/196 (39%)
Adra1bNP_031442.2 7tmA_alpha1B_AR 46..359 CDD:320449 134/508 (26%)
TM helix 1 47..73 CDD:320449 10/25 (40%)
TM helix 2 80..106 CDD:320449 10/25 (40%)
TM helix 3 118..148 CDD:320449 20/29 (69%)
TM helix 4 160..183 CDD:320449 6/22 (27%)
TM helix 5 200..229 CDD:320449 11/28 (39%)
TM helix 6 287..317 CDD:320449 16/29 (55%)
TM helix 7 327..352 CDD:320449 14/24 (58%)
Nuclear localization signal. /evidence=ECO:0000250 368..378 3/9 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..430
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 474..515
Blue background indicates that the domain is not in the aligned region.

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