Protein Alignment 5-HT1B and htr7

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_003199632.2
• Gene: htr7 / 100536080
• -ID: -
• Length: 410
• Species: Danio rerio
• Alignment Length: 586
• Identity: 131/586 - (22%)
• Similarity: 218/586 - (37%)
• Gaps: 236/586 - (40%)

  Fly    42 LTQLVDTTSNLSQIVWNRSINGNGNSNTFDLVDDEQERAAVEF--WLLVKMIAMAVVLGLMILVT 104
            |.::.|||:.|.    ..|...||.            |..|..  :..|:.:.:..||.::..:|
Zfish    27 LNKIHDTTTTLP----TPSFMDNGT------------RCGVPILSYGHVEKVLIGGVLTMLTFLT 75

  Fly   105 IIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG-WILGPELCDIWTS 168
            :.||:.|:.::...:.|:..:|||:.|||||||.||.:|||..::.::..| ||.|...|:::.:
Zfish    76 VCGNLLVVISVCFVKKLKQPSNYLIVSLAVADLSVAVVVMPFVSITDLIGGQWIFGRVFCNVFIA 140

  Fly   169 CDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPD 232
            .||:||||||:.|..|:.|||..:|. :.|...::.:.:..::..||..:..::|.|.|||
Zfish   141 MDVMCCTASIMTLCVISIDRYLGITKPLTYPVRQSGKCMAKIVLSVWLLSASITLPPLFGW---- 201

  Fly   233 YMKRIEEQH-CMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTET 296
             .:.:.:.: |::|||:||.|::|...||:|:.|:|.:|::||.:|:
Zfish   202 -AQNVNDDNVCLISQDLGYTIYSTAVAFYIPMSVMLIMYYRIYRVAK------------------ 247

  Fly   297 DCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGS 361
              |||.:                                                    :.:||.
Zfish   248 --DSAAK----------------------------------------------------HTIAGF 258

  Fly   362 EGAV-ARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLS 425
            ..|. ..||..:.   |:|.:.||                                 ..|.::.|
Zfish   259 PKAEDEESMNCVT---AALKLQRE---------------------------------VEECVSFS 287

  Fly   426 QQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEE 490
            :         |:.|
Zfish   288 R---------LLKS--------------------------------------------------- 292

  Fly   491 GAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMAL 555
                :.||..:                        .|||:|||.||.|:.|||.:||:|||:::.
Zfish   293 ----DRKNISI------------------------FKREQKAAATLGIVVGAFAVCWMPFFLLST 329

  Fly   556 TMSLCKECEIHTAVASLF-----LWLGYFNSTLNPVIYTIFNPEFRRAFKRIL------FGRKAA 609
            .....  |.:..:...|:     |||||.||.:||.||..||.:.|..:..::      ..||.:
Zfish   330 ARPFI--CGLQCSCVPLWVERTLLWLGYANSLINPFIYAFFNRDLRTTYHNLIRCRYRNINRKLS 392

  Fly   610 A 610
            |
Zfish   393 A 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	6/25 (24%)
		TM helix 2	125..151	CDD:320454	15/25 (60%)
		TM helix 3	163..193	CDD:320454	14/29 (48%)
		TM helix 4	204..226	CDD:320454	4/21 (19%)
		TM helix 5	247..276	CDD:320454	13/28 (46%)
		7tm_GPCRs	<525..599	CDD:475119	33/78 (42%)
		TM helix 6	533..555	CDD:410628	12/21 (57%)
		TM helix 7	567..592	CDD:410628	12/29 (41%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	66/198 (33%)
htr7	XP_003199632.2	7tmA_5-HT7	62..376	CDD:320452	117/516 (23%)
		TM helix 1	63..89	CDD:320452	6/25 (24%)
		TM helix 2	96..122	CDD:320452	15/25 (60%)
		TM helix 3	135..165	CDD:320452	14/29 (48%)
		TM helix 4	177..199	CDD:320452	4/21 (19%)
		TM helix 5	216..245	CDD:320452	13/28 (46%)
		TM helix 6	301..331	CDD:320452	17/29 (59%)
		TM helix 7	344..369	CDD:320452	12/24 (50%)