Protein Alignment 5-HT1B and htr1f

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_002931817.1
• Gene: htr1f / 100494586
• XenbaseID: XB-GENE-1010473
• Length: 360
• Species: Xenopus tropicalis
• Alignment Length: 515
• Identity: 146/515 - (28%)
• Similarity: 214/515 - (41%)
• Gaps: 186/515 - (36%)

  Fly    91 IAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG 155
            |.:::.|.::.|:|...|..||||||:.|.|.:.||||:.||||.|..||.||||...:|.:...
 Frog    24 ILISLTLSILTLMTTAINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIMKET 88

  Fly   156 WILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALI 219
            ||:|..:||||.|.|:.|||.|||||.|||.|||..:|: ::|...|||:....||..||..::.
 Frog    89 WIMGQAICDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAAFMIAVVWIISIF 153

  Fly   220 VSLAPQFGWKDPDYMKRIEEQHCMVSQD-VGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQR 283
            :|:.|.| |:.....|   |..|::..| :.:.|::|...||:||.:||.||:|||
 Frog   154 ISMPPLF-WRHQALNK---EDECIIKHDHIVFTIYSTFGAFYIPLALILILYYKIY--------- 205

  Fly   284 RAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICF 348
                            .|.:.|..:||..|.||::              .||
 Frog   206 ----------------KAAKTLYHKRSVSRVEREQ--------------NGQ------------- 227

  Fly   349 GRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDY 413
                                   :.:| |:..:...|..||       .|        |:|.|..
 Frog   228 -----------------------VLLD-ATTTLCIAEKSFS-------DH--------STDFDKI 253

  Fly   414 RTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGA 478
            ..:..|..:.:.|:.|:
 Frog   254 HITVRNARVEMKQEKAY------------------------------------------------ 270

  Fly   479 VAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAF 543
                                                     |:|.:.:.||||||.||.:|.|||
 Frog   271 -----------------------------------------RKQKISSTRERKAATTLGLILGAF 294

  Fly   544 VICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            |||||||||..:.:::|:.|.|...:::...||||.||.:||:||||||.:|::||::::
 Frog   295 VICWLPFFVKEVIVNICESCYISDDMSNFLTWLGYLNSLINPLIYTIFNEDFKKAFQKLM 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	10/25 (40%)
		TM helix 2	125..151	CDD:320454	15/25 (60%)
		TM helix 3	163..193	CDD:320454	20/29 (69%)
		TM helix 4	204..226	CDD:320454	6/21 (29%)
		TM helix 5	247..276	CDD:320454	14/29 (48%)
		7tm_GPCRs	<525..599	CDD:475119	39/73 (53%)
		TM helix 6	533..555	CDD:410628	16/21 (76%)
		TM helix 7	567..592	CDD:410628	12/24 (50%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	82/197 (42%)
htr1f	XP_002931817.1	7tmA_5-HT1F	24..351	CDD:320456	145/510 (28%)
		TM helix 1	25..51	CDD:320456	10/25 (40%)
		TM helix 2	58..84	CDD:320456	15/25 (60%)
		TM helix 3	96..126	CDD:320456	20/29 (69%)
		TM helix 4	138..160	CDD:320456	6/21 (29%)
		TM helix 5	178..207	CDD:320456	13/53 (25%)
		TM helix 6	278..308	CDD:320456	21/29 (72%)
		TM helix 7	318..343	CDD:320456	12/24 (50%)